Prevalência das alterações radiológicas osteoarticulares e suas associações com controle hormonal a funcionalidade e a qualidade de vida em pacientes com acromegalia
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2021-03-19
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Universidade Federal de Goiás
Resumo
Arthropathy is the most prevalent comorbidity of acromegaly, and studies are
inconclusive about its associations with GH/IGF-1 control and/or other clinical features, so
we elected to evaluate the prevalence of radiological arthropathy of lumbar vertebral column
and lower limbs and its associations with quality of life, functionality, joint pain scores, clinical
and psychiatric variables in acromegalic
patients Methods: Cross-sectional study with 40 acromegalic patients of a tertiary Hospital.
Clinical data was retrieved from medical records. WOMAC questionnaire was obtained to
assess pain, stiffness and functionality in lower limbs, AcroQoL for quality-of -life and BDI-II
for depressive symptoms assessment. X-rays of the hands, hips, knees, and lumbar spine
were analyzed by a single radiologist. Osteoarthritis (OA) was graded according to Kellgren
and Lawrence classification. Results: OA prevalence was 87% in lumbar spine, 77.4% in
hips, 68.7% in knees. OA severity was associated with diabetes mellitus in lumbar spine (p
<0.01) and higher IGF-1 levels at diagnosis in knees (p <0.05). No association was found
among OA severity and questionnaires scores, but hypogonadism was significantly
associated with worse WOMAC scores (p <0.05). Female gender was associated with higher
BDI-II score (p <0.05), but not AcroQol or WOMAC. Conclusion: OA prevalence was high;
however, its severity was not associated with acromegaly hormonal control, WOMAC,
AcroQol or BDI-II scores. Modifiable factors as hypogonadism can be as important as
hormonal control in acromegaly for chronic pain management.
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JATENE, N. Prevalência das alterações radiológicas osteoarticulares e suas associações com controle hormonal a funcionalidade e a qualidade de vida em pacientes com acromegalia. 2021. 64 p. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal de Goiás, Goiânia, 2021.