MicroRNAs associados aos mecanismos fisiopatológicos da diabetes mellitus gestacional
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Data
2023-09-19
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Universidade Federal de Goiás
Resumo
Gestational diabetes mellitus (GDM) is a common condition during pregnancy and can
be diagnosed from the beginning of prenatal care. Studies have highlighted the role of
microRNAs (miRNAs) in the pathophysiological mechanism and as possible biomarkers
for the diagnosis and treatment of GDM. miRNAs, a class of small non-coding RNAs,
play a role in post-transcriptional gene expression. Therefore, this study aimed to
perform a systematic review of miRNAs associated with GDM, to build a panel of
miRNAs. A bibliographic search was carried out in PubMed/Medline, Virtual Health
Library (VHL), Web of Science and EMBASE databases, selecting observational studies
in English, without time restriction. The protocol is registered on the PROSPERO
platform (number CRD42021291791). Fifty-five studies were included in this
systematic review, and 82 altered miRNAs in DMG were identified. Furthermore, four
miRNAs were more frequently upregulated in GDM (mir-16-5p, mir-20a-5p, mir-222-
3p and mir-330-3p). The dysregulation of these miRNAs is associated with mechanisms
of cell cycle homeostasis, growth and proliferation of pancreatic β cells, glucose uptake
and metabolism, insulin secretion and resistance. Therefore, identifying miRNAs
associated with GDM and elucidating its main mechanisms can help in the
characterization and definition of possible biomarkers for the diagnosis and treatment
of GDM.
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Citação
SILVA, P. H. C. M. MicroRNAs associados aos mecanismos fisiopatológicos do diabetes mellitus gestacional. 2023. 88 f. Dissertação (Mestrado em Ciências da Saúde) - Faculdade de Medicina, Universidade Federal de Goiás, Goiânia, 2023.