MicroRNAs associados aos mecanismos fisiopatológicos da diabetes mellitus gestacional
dc.contributor.advisor-co1 | Santos, Rodrigo da Silva | |
dc.contributor.advisor-co1Lattes | http://lattes.cnpq.br/4806187026900959 | |
dc.contributor.advisor1 | Reis, Angela Adamski da Silva | |
dc.contributor.advisor1Lattes | http://lattes.cnpq.br/3243656364470085 | |
dc.contributor.referee1 | Reis, Angela Adamski da Silva | |
dc.contributor.referee2 | Soares, Leonardo Ribeiro | |
dc.contributor.referee3 | Franchi, Leonardo Pereira | |
dc.creator | Silva, Pedro Henrique Costa Matos da | |
dc.creator.Lattes | http://lattes.cnpq.br/2762321350163489 | |
dc.date.accessioned | 2023-09-26T18:22:55Z | |
dc.date.available | 2023-09-26T18:22:55Z | |
dc.date.issued | 2023-09-19 | |
dc.description.abstract | Gestational diabetes mellitus (GDM) is a common condition during pregnancy and can be diagnosed from the beginning of prenatal care. Studies have highlighted the role of microRNAs (miRNAs) in the pathophysiological mechanism and as possible biomarkers for the diagnosis and treatment of GDM. miRNAs, a class of small non-coding RNAs, play a role in post-transcriptional gene expression. Therefore, this study aimed to perform a systematic review of miRNAs associated with GDM, to build a panel of miRNAs. A bibliographic search was carried out in PubMed/Medline, Virtual Health Library (VHL), Web of Science and EMBASE databases, selecting observational studies in English, without time restriction. The protocol is registered on the PROSPERO platform (number CRD42021291791). Fifty-five studies were included in this systematic review, and 82 altered miRNAs in DMG were identified. Furthermore, four miRNAs were more frequently upregulated in GDM (mir-16-5p, mir-20a-5p, mir-222- 3p and mir-330-3p). The dysregulation of these miRNAs is associated with mechanisms of cell cycle homeostasis, growth and proliferation of pancreatic β cells, glucose uptake and metabolism, insulin secretion and resistance. Therefore, identifying miRNAs associated with GDM and elucidating its main mechanisms can help in the characterization and definition of possible biomarkers for the diagnosis and treatment of GDM. | por |
dc.description.resumo | O diabetes mellitus gestacional (DMG) é uma frequente durante a gravidez, podendo ser diagnosticada desde o início do pré-natal. Estudos têm destacado o papel dos microRNAs (miRNAs) no mecanismo fisiopatológico e como possíveis biomarcadores para o diagnóstico e tratamento do DMG. miRNAs são uma classe de pequenos RNAs não codificantes, os quais desempenham um papel na expressão gênica póstranscricional. Portanto, este estudo teve como objetivo realizar uma revisão sistemática de miRNAs associados ao DMG, para construir um painel de miRNAs. Foi realizado uma pesquisa bibliográfica nas bases de dados PubMed/Medline, Biblioteca Virtual da Saúde (BVS), Web of Science e EMBASE, selecionando estudos observacionais em inglês, sem restrição de tempo. O protocolo está registrado na plataforma PROSPERO (número CRD42021291791). Cinquenta e cinco estudos foram incluídos nesta revisão sistemática e 82 miRNAs alterados no DMG foram identificados. Além disso, quatro miRNAs foram mais frequentemente regulados positivamente no GDM (mir-16-5p, mir-20a-5p, mir-222-3p e mir-330-3p). A desregulação desses miRNAs está associada a mecanismos de homeostase do ciclo celular, crescimento e proliferação de células β pancreáticas, captação e metabolismo de glicose, secreção e resistência à insulina. Portanto, identificar miRNAs associados ao DMG e elucidar seus principais mecanismos pode auxiliar na caracterização e definição de possíveis biomarcadores para o diagnóstico e tratamento do DMG. | |
dc.identifier.citation | SILVA, P. H. C. M. MicroRNAs associados aos mecanismos fisiopatológicos do diabetes mellitus gestacional. 2023. 88 f. Dissertação (Mestrado em Ciências da Saúde) - Faculdade de Medicina, Universidade Federal de Goiás, Goiânia, 2023. | |
dc.identifier.uri | http://repositorio.bc.ufg.br/tede/handle/tede/13043 | |
dc.language | por | |
dc.publisher | Universidade Federal de Goiás | |
dc.publisher.country | Brasil | |
dc.publisher.department | Faculdade de Medicina - FM (RG) | |
dc.publisher.initials | UFG | |
dc.publisher.program | Programa de Pós-graduação em Ciências da Saúde (FM) | |
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dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | en |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject | DMG | por |
dc.subject | Diabetes | por |
dc.subject | miRNA | por |
dc.subject | Genética | por |
dc.subject | GDM | eng |
dc.subject | Diabetes | eng |
dc.subject | miRNA | eng |
dc.subject | Genetic | eng |
dc.subject.cnpq | CIENCIAS DA SAUDE::MEDICINA | |
dc.title | MicroRNAs associados aos mecanismos fisiopatológicos da diabetes mellitus gestacional | |
dc.title.alternative | MicroRNAs associated with the pathophysiological mechanisms of gestational diabetes mellitus | eng |
dc.type | Dissertação |
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