Programa de Pós-graduação em Ciências Farmacêuticas
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Navegando Programa de Pós-graduação em Ciências Farmacêuticas por Por Área do CNPQ "CIENCIAS DA SAUDE::FARMACIA::ANALISE E CONTROLE E MEDICAMENTOS"
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Item Desenvolvimento de carreador lipídico nanoestruturado contendo filtro UV avobenzona(Universidade Federal de Goiás, 2022-09-30) Sousa, Isabelly Paula; Silva, Luís Antônio Dantas; http://lattes.cnpq.br/0999722983963121; Diniz, Danielle Guimarães Almeida; http://lattes.cnpq.br/6801755844853116; Diniz, Danielle Guimarães Almeida; Silva, Lorena Maione; Mendanha Neto, Sebastião AntônioIntroduction: Avobenzone (AVB) is an organic filter, acting in the ultraviolet (UV) A spectrum. It is a cosmetic ingredient that presents photo-instability, impairing its photoprotective activity. For AVB photoprotection, its molecule must be in conformation, however, exposed to a UV photoisomerization it undergoes, passing to a keto form, which has no protection against UVA radiation. Objective: To develop and characterize a nanostructured lipid carrier (NCL) containing AVB and to evaluate its photostability. Methods: The High Performance Liquid Chromatography (HPLC) method was validated to evaluate the AVB. The AVB compatibility with the selected components was the premeans evaluation of thermal analysis of spectrogravimetry and Fourier transformed infrared (FT-IR) porscopy. AVB solubility was for 24 hours by temperature test, under temperature of 37°C, for 24 hours. Afterwards, the components for the composition of the recommended formulation were selected as reasons according to the literature. For the maintenance of the CLN, the method of inversion of phases with application of microfluidization was used. To characterize the performance of the tests: preliminary stability for 14 days, average stability and follow-up of the formulation, evaluation of polydispersity, 30 days, evaluation of pH parameters, particle size, index index (Pd) and content. The encapsulation efficiency (EE%) was performed by the indirect method. The photo stable study lasted 24 hours and consisted of the evaluation of the NLC containing AVB under UVA radiation. The surface of the nanoencapsulated skin surface, AV was projected for 24 hours, using the Franz interface. Results and discussions: the studies of definition of average size, corroborate for the definition of the components of the CLN, isopropyl myristate, 80 and span 85. After the conclusion of the white CLN, the results of size and PdI of 145.9 ± 57 were obtained. .32 nm and 0.196 ± 0.04, respectively. When an AVB was incorporated into the CLN, 135.77 ± 7.27 nm of mean size and 0.150 ± 0.09 of PdI were obtained. For EE%, the value of 72.82± 1.81% of asset encapsulation was generated. Subsequently, the capacity test was performed, to which the solubilized AVB test was presented and the solubilized AVB presentation of solubilized AVB was presented and tested in how much AVB sampled the sample not presented to exposure. The AVB, did not show permeation of clothes in the skin CLN, having its actions in the skin of the CLN, having its skin. Conclusion: Thermal studies will allow the proper selection of formulation constituents. The functional treatment system developed, with protected CLN photo treatment features, and CLN photo treatment features protective conditions, thus, face to face UV. As for its safety, it is seen that the AVB remained mostly retained in the stratum corneum, it did not present permeation to the skin.Item Perspectivas em pesquisas sobre o gênero Campomanesia; estudos fitoquímicos e investigação de atividades biológicas em Campomanesia guazumifolia (Cambess) O. Berg - Myrtaceae(Universidade Federal de Goiás, 2022-07-05) Steckelberg, Rosa Maria de Brito; Paula, José Realino de; http://lattes.cnpq.br/3191837532986128; Paula, José Realino de; Cardoso, Cláudia Andrea Lima; Morais, Mariana Cristina deIntroduction: One of the challenges of public policies to encourage the use of herbal medicines is the inclusion of more native species, such as those of the Campomanesia genus, among the options for taking advantage of Brazilian biodiversity. Identifying research trends on the genus and species may arouse the interest of researchers so that more native species, such as Campomanesia guazumifolia (C.g) can be integrated into health systems where exotic species predominate. Objectives: To evaluate the scientific production of the genus Campomanesia and main species, especially C.g, in which the leaves of cultivated specimens were the object of pharmacognostic studies, phytochemical profile, essential oil characterization, antioxidant potential and biological activities. Methodology: Scientific production on the genus and species was evaluated using scientometric tools using the Web of Science database and the VOSviewer application. The experimental part consisted of traditional pharmacognostic studies; the essential oil was characterized by means of gas chromatography coupled to a mass spectrometer (GC-MS); the antioxidant potential was evaluated by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging method; larvicidal activity by mortality of Aedes aegypti L3 larvae and the antimicrobial activity was tested by a broth microdilution test. Results and discussion: Brazil leads research on gender and most of them occurred after the implementation of herbal medicine policies. C.g was the species with the highest proportional volume of publications in the last 5 years. The species presented flavonoids, tannins, saponins and triterpenes in its composition. The major compound of the essential oil (EO) was β-caryophyllene. The species showed good antioxidant (leaf extract and powder), larvicidal (EO) and antimicrobial activity, mainly against Candida sp and Micrococcus luteus strains. Conclusions: C. guazumifolia is a promising species for further research on biological activities and other studies that can support the traditional use and also as a phytomedicine.