Programa de Pós-graduação em Física
URI Permanente desta comunidade
Navegar
Navegando Programa de Pós-graduação em Física por Por Programa "Programa de Pós-graduação em Fisica (IF)"
Agora exibindo 1 - 3 de 3
Resultados por página
Opções de Ordenação
Item Estudo das interações dos surfactantes iônicos SDS, CTAC e HPS e miltefosina com membranas de leishmania, macrófagos e eritrócitos(Universidade Federal de Goiás, 2023-09-18) Cardoso, Éder Jéferson Souza; Alonso, Antônio; http://lattes.cnpq.br/5013069863616789; Alonso, Antônio; Mendanha Neto, Sebastião Antônio; Silva, Kleber Santiago Freitas eMiltefosine (MT) is an internationally approved oral drug for the treatment of leishmaniasis, however, its mechanism of action is not yet well established. Understanding the mechanism of action of compounds with leishmanicidal activity is important to help in the search for new drug prototypes with greater activity and fewer side effects. Surfactants are compounds widely used in the industry in the manufacture of soap, shampoos and other cosmetics. They are usually classified according to the molecular charge, and may be nonionic, anionic, cationic or zwitterionic (or amphoteric) when they have a positive and negative charge in the same compound. Electron Paramagnetic Resonance (RPE) spectroscopy associated with the spin-label method was used to compare the interactions of MT and the surfactants Sodium Dodecyl Sulfate (SDS, anionic), Cetyl Trimethyl Ammonium Chloride (CTAC, cationic) and N, N-dimethyl-3-ammonio-1-propanesulfonate (HPS, zwitterionic) with the membranes of Leishmania (L.) amazonensis, erythrocyte and macrophage. All compounds increased the molecular dynamics of membrane proteins; however, SDS caused the smallest increase in parasite and erythrocyte membrane dynamics and was also the least effective in antileishmanial activity, cytotoxicity in macrophages J774.A1 and hemolytic potential in both PBS and whole blood. It was detected, in blood plasma, the albumin stiffness caused by 2.5 mM SDS due to the electrostatic and hydrophobic interactions of the compound with the protein. CTAC did not show significant differences in relation to the other compounds, but at higher cell concentrations (>1x109 cells/mL), it showed high activity against the L. amazonensis promastigotes, besides being the most cytotoxic to macrophages J774.A1. For all the experiments, the zwitterionic molecules HPS and MT did not present significant differences between them. The data suggest the possibility of using cationic or zwitterionic surfactants in formulations containing leishmanicides, aiming at the treatment of cutaneous leishmaniasis.Item Simulação da razão de carga de múons atmosféricos utilizando o CORSIKA(Universidade Federal de Goiás, 2023-10-18) Paulo Júnior, Ademar; Gomes, Ricardo Avelino; http://lattes.cnpq.br/6538341799051577; Gomes, Ricardo Avelino; Peixoto, Carlos José Todero; Valdiviesso, Gustavo do Amaral; Tognini, Stefano Castro; Braghin, Fábio LuisThe muon charge ratio, $R_{\mu} = N_{\mu^{+}}/N_{\mu^{-}}$, is a quantity that can be measured both at at different altitude levels from Earth's surface and in underground experiments. The muons result from the hadronic interactions developed in extensive air showers (EAS) created from the interaction of cosmic rays with nuclei in the atmosphere. The muon charge ratio allows obtaining important information both from the point of view of physics involving cosmic rays, and from the study of the ratio between neutrinos and antineutrinos, $\nu/\bar{\nu}$, since their production is directly connected to the muons. The present work is a study using Monte Carlo simulations of EAS produced by cosmic rays with energy between 100 and $10^{6}$ GeV generated by CORSIKA, using the high energy hadronic interaction models: QGSJETII-04, EPOS -LHC, DPMJET III, SYBILL 2.3c, VENUS and QGSJET01-C. EAS were simulated separately with protons as primaries and He nuclei, and these datasets were combined in the performed analyses. Simulations aimed to verify which one of these hadronic interaction models are able to reproduce the expected behavior for the energies involved considering the increase of $R_{\mu}$ due to the contribution of the kaons to the EAS. It was observed that, to the set formed by protons and He nuclei, with the exception of DPMJET, the other models reproduce an increase in $R_{\mu}$ as a function of the energy of the muons on the surface $E_{\mu }\cos\theta^{*}$. However, when compared to the data obtained in the MINOS, OPERA and CMS experiments, the results, in general, does not reproduce the increase in $R_{\mu}$. Our results show that it would be useful to improve these models so that they can reproduce the expected behavior of the muon charge ratio.Item Estudos de materiais dopados com íons lantanídeos para aplicações em nanotermometria(Universidade Federal de Goiás, 2023-10-31) Silva, Daniel Lopo da; Maia, Lauro June Queiroz; http://lattes.cnpq.br/9454054374479016; Maia, Lauro June Queiroz; Poirier, Gaël Yves; Santana, Ricardo Costa deOptical phenomena such as luminescence of materials depend on several characteristics such as temperature, dopants, crystalline structure, etc. Electromagnetic emissions from materials doped with rare-earth ions can provide thermal information regarding the environment where these materials are inserted. Materials with good thermal sensitivity are considered promising for the development of technologies for nanoscale temperature measurements. In this work, nine samples previously prepared through different synthesis routes such as sol-gel process and modified Pechini were analyzed. The samples studied have matrices of several compounds such as aluminum borates (Al4B2O9) monophasic and embedded in silica, aluminum germanates (Al6Ge2O13) monophasic and embedded in silica, yttrium borates (YBO3) and yttrium aluminum silicates (YAS). Altogether, five trivalent lanthanide ions were used as dopants of the samples: Nd, Eu, Er, Tb and Yb. The emission spectra of the samples were analyzed at seven different temperatures from 25 °C to 55 °C with a variation of 5 °C. Diffuse reflectance spectra were studied to confirm the presence of ions in the matrix and enable the calculation of the energy gap for each sample. From the emission spectrum, photoluminescent intensity ratios (RIFs) were calculated for the calculation of relative thermal sensitivities. The sample that showed the highest value for relative thermal sensitivity (Sr) was the one with the composition YBO3 : Nd3+, Eu3+, Er3+, Yb3+, Tb3+ synthesized at 900°C, presenting a value of Sr = (1,52 ± 0,20) %.K-1 in the temperature range of 35°C and 55°C.