Infecção pelo vírus da hepatite B em pacientes com tuberculose em hospital de referência em Goiânia-GO
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2011-11-28
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Universidade Federal de Goiás
Resumo
Hepatitis B and tuberculosis (TB) are important public health problems. This study aimed to
investigate the epidemiological and molecular profile of the hepatitis B virus (HBV) infection
among patients with TB who were attended at the reference hospital for infectious diseases in
Goiânia, Goiás. A total of 402 patients were interviewed for socio-demographic characteristics,
risk factors for HBV infection and previous hepatitis B vaccination. Blood samples were collected
and sera were tested for HBsAg, anti-HBc, and anti-HBs markers by an enzyme-linked
immunosorbent assay (ELISA). HBsAg reactive samples were tested for HBeAg e anti-HBe
markers by ELISA. HBV DNA was detected in HBsAg and anti-HBc reactive samples by
polymerase chain reaction (PCR). HBV DNA positive samples were genotyped by restriction
fragment length polymorphism (RFLP) and sequencing of the Pre-S/S region. The overall HBV
prevalence infection was 25.6% (95% CI: 21.5-30.2). Age higher or equal 50 years old and
injecting or non-injecting drug use were risk factors associated with HBV infection. HBV DNA
was detected in ten (76.9%) HBsAg reactive samples. Of these, eight were genotyped as genotypes
A (n = 7) and D (n=1). HBV occult infection rate of 14.4% was found among anti-HBc reactive
patients. Only 10.9% had serological evidence of previous HBV vaccination. The high prevalence
and risk factors such as injecting or non-injecting drug use, in addition to the low HBV vaccine
coverage found, should indicate that there is a need for interventions aimed at improving hepatitis
B prevention and control in patients with tuberculosis.
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AIRES, Rodrigo Sebba. Infecção pelo vírus da hepatite B em pacientes com tuberculose em hospital de referência em Goiânia-GO. 2011. 101 f. Tese (Doutorado em Medicina Tropical e Saúde Pública) - Universidade Federal de Goiás, Goiânia, 2011.