Infecção pelo vírus da hepatite B em catadores de materiais recicláveis em Goiânia-Goiás
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Data
2013-01-11
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Universidade Federal de Goiás
Resumo
Hepatitis B virus (HBV) remains a major cause of liver disease worldwide despite
vaccination programs implemented over the last decade. Worldwide, it is estimated that 2
billion people are infected with HBV and that more than 240 million are chronically
infected. Patients with chronic hepatitis B are at risk for developing liver cirrhosis and
hepatocellular carcinoma. Recyclable waste collectors have a lifestyle that is characterized
by unfavorable social and environmental factors. There is currently very little data on HBV
infection in this population. Therefore, the aim of the present study was to investigate the
epidemiological profile of HBV infection in a population of recyclable waste collectors in
Goiânia-GO. A cross-sectional survey was carried out with 431 individuals who were
recruited in all 15 recycling cooperatives in Goiânia-GO. All individuals were interviewed,
and their serum samples were tested for the presence of HBV serological markers. HBsAg
and anti-HBc-positive samples were tested for HBV-DNA by polymerase chain reaction,
and were genotyped by sequencing of the S region. The overall HBV prevalence infection
was 12.8% (95% CI: 9.8-16.2). A multivariate analysis of risk factors showed that age >40
years and illicit drug use were independently associated with HBV infection. HBV-DNA
was detected in 2/3 HBsAg-positive samples, and in 1/52 anti-HBc-reactive samples,
resulting in an occult HBV infection rate of 1.9%. HBV genotypes A (subgenotype A1), D
(subgenotype D3) and F (subgenotype F2) were identified. Only 12.3% of this population
showed serological evidence of previous hepatitis B vaccination. These findings highlight
the need of public health programs to recyclable waste collectors, including the hepatitis B
vaccination.
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MARINHO, Tamíris Augusto. Infecção pelo vírus da hepatite B em catadores de materiais recicláveis em Goiânia-Goiás. 2013. 98 f. Dissertação (Mestrado em Medicina Tropical e Saúde Publica) - Universidade Federal de Goiás, Goiânia, 2013.