Frequência das lesões cutâneas no lúpus eritematoso sistêmico
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Data
2017-08-17
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Universidade Federal de Goiás
Resumo
Systemic lupus erythematosus (SLE) is an autoimmune, systemic, chronic
inflammatory disease. The ACR (American College of Rheumatology) considers 4 skin findings
as attributes for classifying SLE, while the Systemic Lupus International Collaborating Clinics
(SLICC) has added new cutaneous lesions as classification criteria. The purpose of the present
study is to quantify cutaneous lesions in SLE and associate them with other disease elements
(demographics, ANA antibodies, extracutaneous lesions and disease activity) in patients treated at
a renowned reference hospital in Brazil’s center-west region. Methods: Patients diagnosed with
SLE in the HC/FMUFG unit were selected, and 97 of them were enrolled. A clinical
consultation, along with medical records, provided collected data. SLEDAI score was used for
measuring disease activity. The skin findings were categorized in groups according to the
SLICC´s critera. Association and descriptive analysis of the qualitative variables were used,
using absolute (n) and relative (%) frequencies. Results: Subjects were 86 females and 11 males
of mixed ethnicities. Among LE specific lesions, malar rash was predominant, accounting for 33
patients (32.98%). Photosensitivity was found in 30.92% of patients, equivalent of Subacute
Cutaneous Lupus Erythematosus (SCLE), discoid lesions in 9.27%, whilst lupus panniculitis
comprised 3.9%. Hypertrophic and chilblain lupus represented both 2.06%. We found 72.16%
patients with active disease and 81.4% with positive ANA. Conclusions: At least one skin lesion
was present in 60,8% of the patients. In this Brazilian population, malar rash remains the main
presentation of skin lesions in SLE, followed by SCLE and photosensitivity. We found no
important association among skin lesions and SLEDAI score, ethnicity, age or gender. ANA
antibodies was associated with alopecia (both cicatricial and non-cicatricial). Further studies are
necessary in order to establish precise disease activity correlation and guided prognosis through
skin findings. A deeper understanding of cutaneous lesions in SLE may provide a better disease
management.
Descrição
Citação
ROCHA, A. C. N. C. Frequência das lesões cutâneas no lúpus eritematoso sistêmico. 2017. 78 f. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal de Goiás, Goiânia, 2017.