Imunogenicidade e reatogenicidade da vacina contra hepatite B derivada de Hansenula polymorpha comparada a Saccharomyces cerevisiae em homens privados de liberdade
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2019-04-30
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Universidade Federal de Goiás
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Hepatitis B virus infection still poses a serious threat to global health, since there is no
"virological cure" and vaccination, considered the main pillar of eradication of the disease,
did not reach the coverage rates recommended. The objective of this study was to evaluate
the response of the hepatitis B vaccine to men deprived of their liberty from a prison in the
state of Goiás, Central Brazil, comparing a vaccine with Hansenula polymorpha expression
system to Saccharomyces cerevisiae. The participants were divided into two groups - Group
1 (SERUM - Hansenula polymorpha) and Group 2 (EUVAX - Saccharomyces cerevisiae).
Vaccines were administered at months 0, 1 and 6. The Geometric Mean (MGT) of anti- HBs
after the third dose of the vaccine was 656.1 (95% CI: 446.6, 972.7) of G1 and 203.7 (95%
CI: 69.3, 597.0) of G2. Unadjusted analysis showed that G1 MGT was statistically higher
than that observed in G2 (p-value = 0.075). The seroconversion rate (anti-HBs titers> 10
mIU / mL) was 100% for G1 and 82.8% for G2, with a trend toward higher seroconversion
in G1 than G2 (p-value = 0.058). HIV infection (RTIaj 3.76, p-value = 0.035) and obesity
(RTIaj 4.95, p-value = 0.017) were associated with inadequate vaccine response. Regarding
reatogenicity, there was no statistical difference between groups (p-value = 0.501).
Evidence from this investigation shows that the two vaccines, with different expression
systems, were satisfactory in this clinical trial, although all nonresponders belonged to group
2 with Saccharomyces cerevisiae expression system. It is believed to be important to
continue monitoring the performance of these vaccines in adults with a view to improving
their immunogenicity, by assessing the factors that interfere with the vaccine response.
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SANDIM, L. S. Imunogenicidade e reatogenicidade da vacina contra hepatite B derivada de Hansenula polymorpha comparada a Saccharomyces cerevisiae em homens privados de liberdade. 2019. 132 f. Dissertação (Mestrado em Enfermagem) - Universidade Federal de Goiás, Goiânia, 2019.