Histoplasmose disseminada em pacientes com AIDS: características clínico-epidemiológicas e análise espacial em hospital de referência de uma metrópole do centro- oeste brasileiro
Nenhuma Miniatura disponível
Data
2015-05-21
Autores
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade Federal de Goiás
Resumo
The histoplasmosis is an important endemic mycosis caused by Histoplasma
capsulatum. It’s is an AIDS-defining illness. It causes in patients with AIDS,
especially when LT-CD4 + <100 cells./mm³ the disseminated form and has high
letality rates. Although In the metropolitan area of Goiânia a high rate of
disseminated histoplasmosis is observed in patients with AIDS, the real incidence
and risk factors are unknown. Objectives: Describe the clinical-epidemiological
characteristics and the spatial distribution of cases of histoplasmosis in patients
with AIDS in the city of Goiânia and Aparecida de Goiânia. Methods: A descriptive
ecological study conducted in patients from Tropical Diseases Hospital Dr. Anuar
Auad, from January 2003 to July 2014. A standardized survey was applied to
medical records of patients with AIDS and disseminated histoplasmosis with
laboratory confirmation from Goiânia and Aparecida de Goiânia. A statistical
analysis and description of the epidemiological clinical data was performed with
georeferencing, production of maps and spatial analysis. Results: The
disseminated histoplasmosis in AIDS patients has a high incidence in the
metropolitan area of Goiânia and Aparecida de Goiânia, with a total of 166 cases.
Most of the patients were young men with low income and low education level.
Histoplasmosis was AIDS-defining illnesses in 68 patients, and the average LTCD4+
was 70 cels./mm³ to histoplasmosis diagnosis. The main symptoms were:
respiratory, gastrointestinal and cutaneous. The spatial location of the cases were
predominantly aleatory in both cities studied, however two important regions were
detected: one in the east and another in western of Goiania, both close to water
sources. Conclusions: Histoplasmosis is an urban disease with very high
incidence in Goiânia and Aparecida de Goiânia. All cases presented a serious
clinical features and high mortality rates. The treatment is applied in an irregular
manner and does not follow the guidelines recommendations. The cases found are
related to areas of environmental degradation and uncontrolled urbanization. They
were also related to green areas and waterways.
Descrição
Palavras-chave
Citação
FERREIRA, B. S. Histoplasmose disseminada em pacientes com AIDS: características clínico-epidemiológicas e análise espacial em hospital de referência de uma metrópole do centro- oeste brasileiro. 2015. 91 f. Dissertação (Mestrado em Medicina Tropical e Saúde Publica) - Universidade Federal de Goiás, Goiânia, 2015.