Avaliação da atividade genotóxica e antigenotóxica do elagitanino oenoteina B isolado de Eugenia uniflora L.
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2014-02-18
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Universidade Federal de Goiás
Resumo
The species Eugenia uniflora L. belongs to the Myrtaceae family and is known as “pitangueira”.
It is characterized by small fruit trees that have great therapeutic potential. The leaves of E.
uniflora are rich in hydrolyzable tannins, and the ellagitannin oenothein B has been studied for
its remarkable antitumor activity, representing a possibility for the treatment of some cancers.
However, there is a need for evaluation of possible mutagenic, genotoxic and toxic effects,
which may result in damage to the human body. Three doses of oenoteina B (25, 50 and 75
mg/kg) were used in the micronucleus test, and the same doses along with mitomycin C. Five
doses of oenoteina B were used in SOS inductest (10, 20, 50, 100 and 200 μg/plate) to evaluate
the possible genotoxic or antigenotoxic action and examining the cytotoxic or anticytotoxic
activity of this tannin. Our data showed that oenoteina B did not exhibit genotoxic effects, and
furthermore, this ellagitannin demonstrated protective action against micronucleus formation
induced by mitomycin C in mice. The possible use of oenoteina B as a chemopreventive and/or
therapeutic agent still needs further studies using different tests for genotoxicity, applied to longterm,
pre- and post-treatments, to investigate the mechanism of action of this compound.
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SILVA, C. A. Avaliação da atividade genotóxica e antigenotóxica do elagitanino oenoteina B isolado de Eugenia uniflora L.. 2014. 53 f. Dissertação (Mestrado em Biodiversidade Vegetal) - Universidade Federal de Goiás, Goiânia, 2014.