Infertilidade masculina: com oligozoospermia estudo citogenético em indivíduos ou azoospermia
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Data
2015-02-05
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Universidade Federal de Goiás
Resumo
Male infertility affects about half of couples with infertility history and
is considered a multifactorial syndrome, including a broad spectrum of diseases.
Chromosomal abnormalities are a major cause of human infertility and interfere
with spermatogenesis. Infertility in patients with Klinefelter's syndrome (KS) is a
consequence of degeneration of germ cells and that affects about 4% of infertile
men. Objective: To investigate the presence of chromosomal abnormalities in
infertile men with azoospermia or oligozoospermia seen at the Human
Reproduction Laboratory of the Hospital das Clinicas (LabRep -HC) of the Federal
University of Goiás, in 2013. Methodology: Descriptive study. Metaphases were
analyzed in GTG bands obtained from lymphocytes cultures of 20 infertile men
idiopathic causes. Results: The patients' ages ranged from 26-59 years and the
design attempts ranged on average of 5 (± 5.02) years. In 3/20 (15%) patients
were found karyotype 47, XXY (SK) and the rest, 17/20 patients had a normal
karyotype. Conclusion: Genetic testing can help identify which patients would
benefit from the technical reproduction. These studies are relevant because the
assisted reproduction techniques ignore the process of natural selection and some
classic chromosomal abnormalities end some deleterious mutations that could
through generations. Thus, genetic assessment can lead to genetic counseling
and hence the primary and secondary prevention of congenital defects in offspring
of patients with male infertility. This study helps to assess the prevalence of
chromosomal abnormalities in some men treated at LabRep - HC UFG.
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CURADO, R. M. O. F. Infertilidade masculina: com oligozoospermia estudo citogenético em indivíduos ou azoospermia. 2015. 101 f. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal de Goiás, Goiânia, 2015.