Aspectos Inflamatórios e Imunológicos de Pulpites Dentárias Humanas
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2009-09-18
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Universidade Federal de Goiás
Resumo
Immune and inflammatory cells may contribute to host defense
and microenvironmental changes during the pathogenesis of dental pulpitis.
This study evaluated the microscopic characteristics and densities (per mm2)
of tryptase+ mast cells, CD4+ T helper lymphocytes, CD45RO+ memory T
lymphocytes, foxp3+ T regulatory lymphocytes, CD20+ B lymphocytes, CD68+
macrophages, and CD31+ blood vessels in human dental pulpitis (n = 38).
Methods: Tryptase, CD4, CD45RO, foxp3, CD20, CD68, and CD31
expressions were analyzed using immunohistochemistry; other microscopic
features, such as intensity of inflammatory infiltrate and collagen deposition,
were evaluated after staining with hematoxylin and eosin. Results: Two
microscopic patterns of dental pulpitis were found: group 1 (G1) (n = 15)
showed intense inflammatory infiltrate and mild collagen deposition;
conversely, group 2 (G2) (n = 23) showed scarce inflammatory infiltrate and
intense collagen deposition. The numbers of CD68+ and CD20+ cells and the
density of blood vessels were higher in G1 than in G2. However, there were
no differences in CD4+ and CD45RO+ cell densities between groups. When
present, mast cells were equally distributed in G1 and G2, whereas foxp3+
cells were detected in 58.82% and 14.28% of the samples of G1 and G2.
Conclusions: Immune and inflammatory cell infiltration have different
patterns in human dental pulpitis, which might reflect distinct microscopic
characteristics and particular local defense capabilities.
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Citação
BRUNO, Kely Firmino. Inflammatory and Immunological Aspects of pulpitis
Human Dental. 2009. 83 f. Tese (Doutorado em Ciencias da Saude) - Universidade Federal de Goiás, Goiânia, 2009.