Doutorado em Ciências da Saúde (FM)
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Item Esteroides Anabolizantes como Recurso Ergogênico no Treinamento Físico: Estudo Qualiquantitativo e Experimental(Universidade Federal de Goiás, 2015-10-02) Cruz, Anderson Miguel da; Castro, Carlos Henrique; http://lattes.cnpq.br/6354834854727314; Silva, Maria Sebastiana; http://lattes.cnpq.br/1329422634395496; Silva, Maria Sebastiana; Barbosa, Maria Alves; Schmidt, Ademir; Mota, João Felipe; Cominetti, CristianeRegular physical exercise is no longer just leisure option to configure how important adjuvant health strategy. It is inserted in human society since ancient times, linked to war practices, circus, sports and even the survival needs. Nowadays, conducting physical training, especially the force, is part of the practices related to aesthetics, the cult of the body and targeted therapies for body health. For these reasons it is configured as an object of study with singular significance and potential. The combination with pharmacological and nutritional resources may result in the improvement of nosological tables and health upsurge in various situations. Some peculiarities largely fostered by consumer media and the cultural socio make the combination of physical training and use of ergogenic agents hormonal an everyday procedure, for athletes and non-athletes by setting a non-clinical use, classified as self-medication. Objectives: To systematize empirical data related to customs and procederes employed by users of anabolic-androgenic steroids, identify the toxicological composition of the main supplements / drugs found, employed in the fitness area and high sports performance; verify the change in total body mass and bone morphometry of young Wistar rats. Methodology: The study follows a sequential motion in two phases with different dynamics and instruments. Phase I consists of an ethnographic study (quantitative and qualitative) with adults in the city of Goiania, anabolic steroids users, through in-depth interview (recorded) from semi-structured questionnaire (N = 40). Phase II is a biomedical study (toxicology and preclinical). From the pharmacological and supplements / drugs raised in phase I, was made toxicological analysis (HPLC) to identify the chemical composition (Phase IIa), and the systematic use of procedures (structure of courses). The preclinical study designed to investigate the plyometric strength training interaction (in pool with increasing load based on body weight) combined with use of Stanazolol, 0.85 mg / dose. Main results are apresentdos in four articles, 01 with qualiquantitativas features 01 with quantiqualitative profile and 02 with quantitative traits. Most prte of users (75%) admits the use of hormonal anabolic steroids for non-athletes and recognize precisely the potential side effects. Among the most frequently cited drugs, Decadurabolin, Stanazolol and Durateston were the most cited in use alone or in double and triple combinations. The media is seen as highly influential in the choice of the use and trade of ergogenic agents. It featured the use "non-clinical, automedicado" and the practice of polypharmacy. The systematic use is not uniform and displays strong methodological inconsistencies derived from empirical studies conducted by bodybuilding athletes and appropriate inadvertently by the population "non-athlete". The toxicological analysis supplements / medications points out that the composition of the products do not fully contemplate the use of purpose beyond incoherence of the labels, since they do not contain products that hint at the labels and commercial brochures. In preclinical studies (Wistar rat young) there was no significant change in the morphology of the tibia during "one" stanazolol cycle (12 doses). Total body mass showed statistically significant changes for the trained group, trained / medicated and only medicated. Final thoughts: The plyometric strength training (short Abstract xix duration and high intensity), enabled the reduction of total body mass (with and without stanazolol), suggesting that it can be then used in obesity control strategies, enabled a reduction in the index growth of treated animals.Item Efeito agudo de intervenções musicoterapêuticas no controle da dor e outros sintomas em pacientes hospitalizados em cuidados paliativos(Universidade Federal de Goiás, 2025-04-25) Santos, Elvira Alves dos; Zanini, Claudia Regina de Oliveira; http://lattes.cnpq.br/8042694592747539; Sousa, Ana Luiza Lima; http://lattes.cnpq.br/6578713509935374; Sousa, Ana Luiza Lima; Bergold, Leila Brito; Hagemann, Paula de Marchi Scarpin; Suzuki, Karina; Batista, Sandro Rogerio RodriguesEmbargadoItem Efeito do protocolo de limpeza intrarradicular pós preparo para pino na adaptação marginal do agente de cimentação à dentina radicular(Universidade Federal de Goiás, 2023-07-11) Boggian, Luciana Carvalho; Estrela, Carlos; http://lattes.cnpq.br/3611967334176683; Estrela, Carlos; Bernardes, Cristiane Martins Rodrigues; Guedes, Orlando Aguirre; Silva, Julio Almeida; Barletta, Fernando BrancoEmbargadoItem Comparação entre os efeitos agudos de um exergame versus exercício contínuo tradicional sobre os sintomas de ansiedade-estado em mulheres jovens previamente expostas a estímulos desagradáveis(Universidade Federal de Goiás, 2024-12-20) Silva, Wellington Fernando da; Viana, Ricardo Borges; http://lattes.cnpq.br/5907695308629566; Lira, Claudio Andre Barbosa de; http://lattes.cnpq.br/3289964716112944; Lira, Claudio Andre Barbosa de; http://lattes.cnpq.br/3289964716112944; Andrade, Marilia dos Santos; http://lattes.cnpq.br/8618739762906389; Schuch, Felipe Barreto; http://lattes.cnpq.br/6306568661892387; Oliveira, Bruno Ribeiro Ramalho de; http://lattes.cnpq.br/8811356725465308; Rosa, João Paulo Pereira; http://lattes.cnpq.br/8729014169198434EmbargadoItem Comparação entre dois aparelhos de angiotomografia de coerência óptica (Triton e Mocean) na avaliação da microvasculatura foveal em indivíduos com diabetes(Universidade Federal de Goiás, 2023-12-13) Simões, Heitor do Amaral; Isaac, David Leonardo Cruvinel; http://lattes.cnpq.br/5474072354473614; Ávila, Marcos Pereira de; http://lattes.cnpq.br/3335187297522447; Ávila, Marcos Pereira de; Silva, Leopoldo Magacho dos Santos; Taleb, Alexandre Chater; Lima, Francisco Eduardo Lopes de; Casella, Antônio Marcelo BarbantexxxxItem A relação médico-paciente no ensino da medicina: desafios e possibilidades(Universidade Federal de Goiás, 2024-12-12) Elias, Berta Baltazar; Vandenberghe, Luc Marcel; Rassi, Salvador; http://lattes.cnpq.br/7236834842677715; ; Rassi, Salvador; Naghettini, Alessandra Vitorino; Pereira, Edna Regina da Silva; Chaves, Sandramara Matias; Jardim, Paulo César Brandão VeigaEmbargado.Item Análise do perfil clínico e funcional de indivíduos com sintomas pós COVID - 19(Universidade Federal de Goiás, 2024-10-11) Oliveira, Jordana Campos Martins de; Silva, Lucas Raphael Bento; http://lattes.cnpq.br/5740390090008809; Rebelo, Ana Cristina Silva; http://lattes.cnpq.br/1542664015677213; Rebelo, Ana Cristina Silva; Goulart, Cássia da Luz; Vento, Daniella Alves; Vieira, Carlos Alexandre; Guimarães, Valeriana de CastroEmbargada.Item Comparação dos efeitos fisiológicos e psicobiológicos de uma única sessão de exercício físico tradicional e em realidade virtual imersiva em adultos jovens expostos a estímulos desagradáveis: um ensaio clínico randomizado(Universidade Federal de Goiás, 2025-04-16) Lima, Bráulio Evangelista de; Morais, Naiane Silva; http://lattes.cnpq.br/2471333629874744; Lira, Claudio Andre Barbosa de; http://lattes.cnpq.br/3289964716112944; Lira, Claudio Andre Barbosa de; Rosa, João Paulo Pereira; Viana, Ricardo Borges; Santana, Marcos Gonçalves de; Campos, Mário HeblingEmbargadoItem Fatores genéticos e evolução de fetos com anomalias urinárias(Universidade Federal de Goiás, 2024-11-09) Pôrto, Maria Laura de Almeida; Pinto, Irene Plaza; http://lattes.cnpq.br/0606687569347456; Amaral, Waldemar Naves do; http://lattes.cnpq.br/4092560599116579; Amaral, Waldemar Naves do; Ferreira, Rui Gilberto; Sousa, Juarez Antônio de; Rios, Washington Ferreira; Franco, Glaucimeire MarquezEmbargada.Item Ensaio clínico aleatório duplo-cego placebo controlado do uso do cetorolaco de trometamina para realização de mamografia(Universidade Federal de Goiás, 2008-09-10) Silveira Júnior, Luiz de Paula; Freitas Júnior, Ruffo de; http://lattes.cnpq.br/7343840830786566; Freitas Júnior, Ruffo de; Barbosa, Maria Alves; Moreira, Marise Amaral Rebouças; Conde, Delio Marques; Paulinelli, Regis ResendeEmbargadaItem Perfil das habilidades pragmáticas em crianças com transtorno do espectro autista(Universidade Federal de Goiás, 2025-03-14) Borges, Marcos Henrique; Fernandes, Fernanda Dreux Miranda; http://lattes.cnpq.br/0191175314768692; ; Guimarães, Valeriana de Castro; http://lattes.cnpq.br/6222102545181441; ; Guimarães, Valeriana de Castro; Leite, Rita de Cássia Duarte; Martín, Dolores Rodríguez; Costa, Paulo Sérgio Sucasas da; Barbosa, Maria AlvesEmbargado..Item Consumo alimentar e adenocarcinoma gástrico: um enfoque epidemiológico em Goiás(Universidade Federal de Goiás, 2025-02-25) Santiago, Silvana Barbosa; Curado, Maria Paula; http://lattes.cnpq.br/3397823736381748; Curado, Maria Paula; Vilela, Ana Amélia Freitas; Santos, Thays Angélica de Pinho; Vasconcelos, Lara Stefânia Netto de Oliveira Leão; Schincaglia, Raquel MachadoBackground: The dietary profile of people from Goiás is characterized by unhealthy food choices. Little is known about the influence of diet and gastric adenocarcinoma. Method: A case-control study was conducted to investigate the association between the dietary intake of gastric adenocarcinoma (AdG) cases and controls in Goiânia between March 2019 and September 2024. The dietary patterns of AdG cases and controls were identified by exploratory factor analysis (EFA). The associations between dietary intake and AdG were verified by binary logistic regression analysis, which was used to estimate the odds ratios between the consumption of processed meats and AdG. All tests considered a significant level of 5%. Results: The main dietary pattern of AdG cases was healthy. Among cases and endoscopic controls, consumption of processed meats equal to or greater than 16 g/day increased the odds of AdG when compared to those with lower consumption (OR 3.16, 95% CI: 1.67; 5.96). Among cases and hospital controls, no increased odds of AdG were observed (OR 1.17, 95% CI: 0.62; 2.20). Conclusion: The healthy dietary pattern of AdG cases is not a determinant of gastric carcinogenesis. Consumption equal to or greater than 16 g/day of processed meat can be considered a risk factor for AdG. These findings have important implications for public health; a better understanding of diet-related risk factors for AdG can be considered in the design of effective and low-cost programs to improve the prevention of this neoplasia, especially in individuals undergoing endoscopy.Item Avaliação das interações entre cirurgiões-dentistas, cuidadores e crianças com medo e ansiedade odontológica(Universidade Federal de Goiás, 2025-01-23) Teles, Graziele Lopes; Costa, Luciane Ribeiro de Rezende Sucasas da; http://lattes.cnpq.br/9906371509661305; Costa, Luciane Ribeiro de Rezende Sucasas da; Costa Junior, Áderson Luiz; Moreira, Francine do Couto Lima; Machado, Geovanna de Castro Morais; Tavares, Naraiana de OliveiraEmbargado.Item Acurácia Diagnóstica Daelastografia Hepática E Da Ultrassonografiano Estadiamento Da Fibrose Em Pacientes Com Doença Hepática Esteatótica MetabólicA(Universidade Federal de Goiás, 2025-02-22) Parente, Ariela Mauller Vieira; Aires, Rodrigo Sebba; Amaral, Waldemar Naves do; http://lattes.cnpq.br/4092560599116579; Amaral, Waldemar Naves do; Ferreira , Rui Gilberto; Sousa, Juarez Antônio de; Moraes, Alexandre Vieira santos; Silva, Luciano Lucindo daembargoed.Item Estudo farmacocinético do protótipo de fármaco antineoplástico LQFM018 em modelos pré-clínicos(Universidade Federal de Goiás, 2016-07-15) Rodrigues, Caroline Rego; Cunha, Luiz Carlos da; Cunha, Luiz Carlos da; Guillo, Lídia Andreu; Teixeira, Leonardo de Souza; Alves, Carina Pimentel Itapema; Ghedini, Paulo CésarLQFM 018 is an antitumor prototype synthesized from molecular simplification of nutlin-3a and demonstrated activity against K-562 leukemia cells. This work sought to evaluate LQFM018 pharmacokinetics and bioavailability in mice and to determine possible drug interactions it maybe will cause when administered along with drugs metabolized by CYP3A microsomal enzymes family. For this purpuse, LQFM018 solutions were injected in mice via a tail vein at a single dose of 10 mg/kg (i.v.); intraperitoneally at doses of 25, 50 and 100 mg/kg (i.p.) and orally at a dose of 100 mg/kg (p.o.). Blood samples were collected over 24 hours by cardiac punction and LQFM018 concentration were determined by validated HPLC MS/MS method. The following pharmacokinetics parameters were obtained by WinNonlin 5.0 software (Pharsight): area under the time vs concentration curve (AUCT), maximal concentration (Cmax) and time to reach it (Tmax), apparent volume of distribution (Vd), elimination half-life (t1/2) and total clearance (ClT). Absolute bioavailability were calculated by bioavailable fraction of the systemic circulation (F%). Results were extrapolated to humans by allometric scale. AUCT values were proportional to dose after i.p. administration suggesting linear kinetics. The mean elimination half-lives were 4.37 ± 0.11 h p.o. and i.p., and 1.5 ± 0.45 h i.v. For extravascular administrations, Vd = 5.33 ± 1.05 L/kg, F values were 41.0 ± 6.98 % suggesting pre-systemic elimination (ClT values were 13.9 ± 2.76 mL/min/kg). Double peaks in time versus concentration curve, at elimination phase, suggest enterohepatic recirculation. In order to verify the ability of LQFM018 to inhibit liver enzyme CYP3A in rats, this enzymes were tested as the capacity of midazolam metabolization in the presence and in the absence of LQFM018 for evaluate inhibitory effect. LQFM018 demonstrated partial inhibitory activity on in vitro CYP3A enzymes when the highest concentration was tested (100 µg/mL). In LQFM018 average concentration (50 µg/mL) there was 56% of inhibition; LQFM018 tested at low concentration (10 µg/mL) did not interfere with the metabolism of CYP3A enzymes. The results show that LQFM018 is an antitumor prototype highly distributed (with great penetrating power, due to its apparent high Vd) may be used in the future for the treatment of deep tumors. Its high value of CLT shows that it is quickly eliminated, which is corroborated by the low value of t1/2 . These features combined with linear kinetics are pharmacokinetic advantages, but its high Vd values suggests that this molecule can undergo accumulation in tissues. The enterohepatic circulation and the ability to inhibit CYP3A enzymes by LQFM018 are parameters to be evaluated when administered in multiple doses. This work should provide a basis for future LQFM018 pharmacokinetic tests.Item Estudo comparativo entre a técnica Scuba mofificado e um novo modelo de câmara artificial na manutenção da integridade macroscópica do preparo do complexo endotélio - descemet para o transplante endotelial da córnea(Universidade Federal de Goiás, 2024-05-14) Moraes Filho, Leiser Franco de; Isaac, David Leonardo Cruvinel; Silva, Leopoldo Magacho dos Santos; http://lattes.cnpq.br/8749557033319190; Silva, Leopoldo Magacho dos Santos; Ávila, Marcos Pereira de; Beniz Neto, Jose; Nassaralla, Belquiz Rodrigues de Amaral; Louzada, Ricardo NogueraThis study is intended to compare the preparation time and the macroscopic integrity of Descemet’s membrane-endothelium complex for endothelial corneal transplantation with DMEK between the modified SCUBA technique and the use of new artificial chamber that works with the inverted cornea. This is a prospective, comparative, randomized and experimental study performed at CEROF-UFG. Fifty corneas from 25 donors were used, including both eyes of the same donor, scleral ring greater than 3 mm, corneas not suitable for clinical use. Preparation time and macroscopic tissue integrity at the end of preparation were evaluated. The median preparation time for both techniques was six minutes (p=0.290). The macroscopic integrity of the graft was similar between the inverted artificial chamber technique and the modified SCUBA technique (p=1.00). Macroscopic integrity was consider as grafts with tears smaller than 2 mm from the edge of the tissue after 8 mm trepanation. The artificial chamber that operates with the inverted cornea proved to be reproducible and suitable for endothelial graft preparation for the DMEK technique.Item Velocidade de onda de pulso de 8,2m/s para identificação de biomarcadores em pacientes hipertensos(Universidade Federal de Goiás, 2022-08-08) Inuzuka, Sayuri; Vitorino, Priscila Valverde de Oliveira; http://lattes.cnpq.br/1815619227221108; Souza, Weimar Kunz Sebba Barroso de; http://lattes.cnpq.br/6847019017274804; Souza, Weimar Kunz Sebba Barroso de; Brandão, Andrea Araújo; Miranda, Roberto Dischinger; Jardim, Paulo Cesar Brandão Veiga; Sousa, Ana Luiza LimaBackground: Which pulse wave velocity (PWV) value has the greatest association with biomarkers remains poorly understood. Objective: Identify from which pulse wave velocity (PWV) value, there is a greater possibility of identifying association with the presence of left ventricular hypertrophy (LVH), increased intima-media thickness (IMT) and presence of carotid plaque in hypertensive patients. Methods: This is a cross-sectional study of patients submitted to the measurement of central (oscillometric method) and peripheral blood pressure (automatic devices) parameters. Carried out between October / 2018 to March / 2019. ROC curves were constructed to estimate the discriminating power of the independent variables to identify the interquartile value of PWV association with biomarkers. The univariate logistic regression model was applied to identify the probability of TOD according to the different scores and to establish sensitivity and specificity of each predictor. The analyses were performed considering the significance level of 0.05. Results: 119 patients were evaluated. The mean age was 60.38 years (± 10.31) and 69,75% were women. An analysis of the sensitivity and specificity (ROC curve) of each biomarker IMT, LVMI and carotid plaque was performed at the cut-off points corresponding to the PWV 8.1, 8.2 and 8.7 m/s of the sample. PWV above 8.2ms was associated with increased IMT (p = 0.004), with the presence of carotid plaque (p = 0.003) and with left ventricular hypertrophy (LVH) (p<0.001). PWV above 8.2 showed greater sensitivity for IMT (AUC = 0.678, sensitivity 62.2), LVH (AUC = 0.717, sensitivity 87.2) and presence of plaque (AUC = 0.649, sensitivity 74.51) in the ROC curve. Conclusion: The 8.2m/s value is more sensitive in identifying the existence of increased IMT, presence of carotid plaque and LVH prematurely. These findings may indicate which value of PWV would be ideal for classifying as normal values.Item Avaliação clínica e molecular do efeito do laser de baixa potência no controle da mucosite oral radio e quimioinduzida em pacientes com câncer na região de cabeça e pescoço: ensaio clínico randomizado(Universidade Federal de Goiás, 2014) Leite, Angélica Ferreira Oton; Mendonça, Elismauro Francisco de; Batista, Aline Carvalho; Silva, Tarcília Aparecida; Alves, Fábio de Abreu; Celes, Mara Rúbia Nunes; Oliveira, José Carlos de; Rotta, Rejane Faria Ribeiro-Item Desenvolvimento do raciocínio clínico em estudantes de medicina do primeiro ao quinto ano(Universidade Federal de Goiás, 2015-02-03) Roberti, Alexandre; Pereira, Edna Regina Silva; Costa, Nilce Maria da Silva Campos; Costa, Nilce Maria da Silva Campos; Amaral, Eliana do; Porto, Celmo Celeno; Lima, Fátima Maria Lindoso da Silva; Taleb, Alexandre ChaterINTRODUCTION: There is a partial understanding of the clinical reasoning development. The SCT usage is not common in Brazil. OBJECTIVES: We aimed to analyze the clinical reasoning development and the SCT application in a medical school of a brazilian university. METHODS: analytical, descriptive research, quantitative/qualitative with SCT and focus groups. The test had ten clinical cases in Internal Medicine, which has been accomplished with reference panel. The study has five focus groups, eight of each year, from first to fifth year. RESULTS: Participated 159/550 academics in the SCT. In SCT preclinical phase the average was 51.6% and clinical phase 63.4% of the maximum. We found significant difference (40%) of study items. Cronbach's Alpha of 0,64. Participated 40/159 academics in focus groups. The content of the speech was divided into clinical reasoning and knowledge of the basic disciplines. DISCUSSION: In the SCT senior performed better. The construction of SCT is not easy. The low reliability because: problems in construction, panel limitations and punctuation key. In preclinical phase reasoning is based on the basic disciplines and clinical phase pattern recognition. 80.6% perceived use of basic disciplines. CONCLUSION: In the pre-clinical phase, the reasoning is dependent on the basic disciplines and clinical phase pattern recognition. The SCT is a difficult application instrument.Item Avaliação do tempo de trânsito orocecal e do teste de tolerância à glicose em pacientes chagasicos e não chagasicos com ou sem constipação intestinal(Universidade Federal de Goiás, 2014-06-10) Bafutto, Mauro; Oliveira, Ênio Chaves de; Oliveira, Ênio Chaves de; Rezende Filho, Joffre; Alves Neto, Onofre; Silva, Nilsio Antônio da; Ramos, Gilson CassenBackground : Most patients with chagasic megacolon presents constipation. However in about one third of patients, despite the megacolon, bowel habits are normal.On the other hand, Chagasic patients may show constipation without evidence of colonic involvement.Thus, the determining factors of constipation in Chagas disease, are not completely understood. The question then arises: if it's not the megacolon solely responsible for constipation, what other factors are involved? In an attempt to answer this question, we evaluated the possibility of involvement not only of the colon, but also of the small intestine, very important organ in the absorption of nutrients and the formation of fecal bolus. This study evaluated whether there is change on orocecal transit and glucose absorption in the small intestine of Chagasic patients and non Chagasic with or without constipation by orocecal transit time measurement and the oral glucose tolerance test. Methods :Six groups of patients were studied: 1) – control group-Without constipation without megacolon and negative for Chagas disease serology; 2)-With constipation without megacolon and negative serology for Chagas disease; 3)-With constipation without megacolon and positive serology for Chagas disease; 4)-Without constipation without megacolon and positive serology for Chagas disease, 5)-With constipation with megacolon and positive serology for Chagas disease. 6)-Without constipationwith megacolon and positive serology for Chagas disease. For measurement of the orocecal transit time was used the H2 expired test. Results : It was observed a great extension of this time in the Group of patients with chagasic megacolon and constipation, which was statistically significant (p=0,001) when compared to all the other groups studied. It was observed that this time is greater in constipated than not constipated (p=0,005). The oral glucose tolerance test used in the evaluation of glycemic curve, showed that blood glucose levels were lower in Chagas disease patients, with statistically significant difference in relation to patients with Chagasic constipation and/or megacolon at 30 (p=0,003),60(p=0,005) e 90 minutes (p=0,001). It was interesting to note that patients with constipation and megacolon, were the only ones among all groups, which showed statistically significant difference at the same time both for the glucose tolerance test as to orocecal transit time. In conclusion, Chagasic patients with constipation and megacolon the orocecal transit time is delayed and during glucose tolerance test present highest rates of blood glucose.These data can correspond to a dysfunction of peristalsis and glucose absorption in the small intestine in patients with Chaga´s disease presenting with megacolon and constipation.