Doutorado em Ciências da Saúde (FM)

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Consumo alimentar e adenocarcinoma gástrico: um enfoque epidemiológico em Goiás
(Universidade Federal de Goiás, 2025-02-25) Santiago, Silvana Barbosa; Curado, Maria Paula; http://lattes.cnpq.br/3397823736381748; Curado, Maria Paula; Vilela, Ana Amélia Freitas; Santos, Thays Angélica de Pinho; Vasconcelos, Lara Stefânia Netto de Oliveira Leão; Schincaglia, Raquel Machado
Background: The dietary profile of people from Goiás is characterized by unhealthy food choices. Little is known about the influence of diet and gastric adenocarcinoma. Method: A case-control study was conducted to investigate the association between the dietary intake of gastric adenocarcinoma (AdG) cases and controls in Goiânia between March 2019 and September 2024. The dietary patterns of AdG cases and controls were identified by exploratory factor analysis (EFA). The associations between dietary intake and AdG were verified by binary logistic regression analysis, which was used to estimate the odds ratios between the consumption of processed meats and AdG. All tests considered a significant level of 5%. Results: The main dietary pattern of AdG cases was healthy. Among cases and endoscopic controls, consumption of processed meats equal to or greater than 16 g/day increased the odds of AdG when compared to those with lower consumption (OR 3.16, 95% CI: 1.67; 5.96). Among cases and hospital controls, no increased odds of AdG were observed (OR 1.17, 95% CI: 0.62; 2.20). Conclusion: The healthy dietary pattern of AdG cases is not a determinant of gastric carcinogenesis. Consumption equal to or greater than 16 g/day of processed meat can be considered a risk factor for AdG. These findings have important implications for public health; a better understanding of diet-related risk factors for AdG can be considered in the design of effective and low-cost programs to improve the prevention of this neoplasia, especially in individuals undergoing endoscopy.
Avaliação das interações entre cirurgiões-dentistas, cuidadores e crianças com medo e ansiedade odontológica
(Universidade Federal de Goiás, 2025-01-23) Teles, Graziele Lopes; Costa, Luciane Ribeiro de Rezende Sucasas da; http://lattes.cnpq.br/9906371509661305; Costa, Luciane Ribeiro de Rezende Sucasas da; Costa Junior, Áderson Luiz; Moreira, Francine do Couto Lima; Machado, Geovanna de Castro Morais; Tavares, Naraiana de Oliveira
Embargado.
Acurácia Diagnóstica Daelastografia Hepática E Da Ultrassonografiano Estadiamento Da Fibrose Em Pacientes Com Doença Hepática Esteatótica MetabólicA
(Universidade Federal de Goiás, 2025-02-22) Parente, Ariela Mauller Vieira; Aires, Rodrigo Sebba; Amaral, Waldemar Naves do; http://lattes.cnpq.br/4092560599116579; Amaral, Waldemar Naves do; Ferreira , Rui Gilberto; Sousa, Juarez Antônio de; Moraes, Alexandre Vieira santos; Silva, Luciano Lucindo da
embargoed.
Estudo farmacocinético do protótipo de fármaco antineoplástico LQFM018 em modelos pré-clínicos
(Universidade Federal de Goiás, 2016-07-15) Rodrigues, Caroline Rego; Cunha, Luiz Carlos da; Cunha, Luiz Carlos da; Guillo, Lídia Andreu; Teixeira, Leonardo de Souza; Alves, Carina Pimentel Itapema; Ghedini, Paulo César
LQFM 018 is an antitumor prototype synthesized from molecular simplification of nutlin-3a and demonstrated activity against K-562 leukemia cells. This work sought to evaluate LQFM018 pharmacokinetics and bioavailability in mice and to determine possible drug interactions it maybe will cause when administered along with drugs metabolized by CYP3A microsomal enzymes family. For this purpuse, LQFM018 solutions were injected in mice via a tail vein at a single dose of 10 mg/kg (i.v.); intraperitoneally at doses of 25, 50 and 100 mg/kg (i.p.) and orally at a dose of 100 mg/kg (p.o.). Blood samples were collected over 24 hours by cardiac punction and LQFM018 concentration were determined by validated HPLC MS/MS method. The following pharmacokinetics parameters were obtained by WinNonlin 5.0 software (Pharsight): area under the time vs concentration curve (AUCT), maximal concentration (Cmax) and time to reach it (Tmax), apparent volume of distribution (Vd), elimination half-life (t1/2) and total clearance (ClT). Absolute bioavailability were calculated by bioavailable fraction of the systemic circulation (F%). Results were extrapolated to humans by allometric scale. AUCT values were proportional to dose after i.p. administration suggesting linear kinetics. The mean elimination half-lives were 4.37 ± 0.11 h p.o. and i.p., and 1.5 ± 0.45 h i.v. For extravascular administrations, Vd = 5.33 ± 1.05 L/kg, F values were 41.0 ± 6.98 % suggesting pre-systemic elimination (ClT values were 13.9 ± 2.76 mL/min/kg). Double peaks in time versus concentration curve, at elimination phase, suggest enterohepatic recirculation. In order to verify the ability of LQFM018 to inhibit liver enzyme CYP3A in rats, this enzymes were tested as the capacity of midazolam metabolization in the presence and in the absence of LQFM018 for evaluate inhibitory effect. LQFM018 demonstrated partial inhibitory activity on in vitro CYP3A enzymes when the highest concentration was tested (100 µg/mL). In LQFM018 average concentration (50 µg/mL) there was 56% of inhibition; LQFM018 tested at low concentration (10 µg/mL) did not interfere with the metabolism of CYP3A enzymes. The results show that LQFM018 is an antitumor prototype highly distributed (with great penetrating power, due to its apparent high Vd) may be used in the future for the treatment of deep tumors. Its high value of CLT shows that it is quickly eliminated, which is corroborated by the low value of t1/2 . These features combined with linear kinetics are pharmacokinetic advantages, but its high Vd values suggests that this molecule can undergo accumulation in tissues. The enterohepatic circulation and the ability to inhibit CYP3A enzymes by LQFM018 are parameters to be evaluated when administered in multiple doses. This work should provide a basis for future LQFM018 pharmacokinetic tests.
Estudo comparativo entre a técnica Scuba mofificado e um novo modelo de câmara artificial na manutenção da integridade macroscópica do preparo do complexo endotélio - descemet para o transplante endotelial da córnea
(Universidade Federal de Goiás, 2024-05-14) Moraes Filho, Leiser Franco de; Isaac, David Leonardo Cruvinel; Silva, Leopoldo Magacho dos Santos; http://lattes.cnpq.br/8749557033319190; Silva, Leopoldo Magacho dos Santos; Ávila, Marcos Pereira de; Beniz Neto, Jose; Nassaralla, Belquiz Rodrigues de Amaral; Louzada, Ricardo Noguera
This study is intended to compare the preparation time and the macroscopic integrity of Descemet’s membrane-endothelium complex for endothelial corneal transplantation with DMEK between the modified SCUBA technique and the use of new artificial chamber that works with the inverted cornea. This is a prospective, comparative, randomized and experimental study performed at CEROF-UFG. Fifty corneas from 25 donors were used, including both eyes of the same donor, scleral ring greater than 3 mm, corneas not suitable for clinical use. Preparation time and macroscopic tissue integrity at the end of preparation were evaluated. The median preparation time for both techniques was six minutes (p=0.290). The macroscopic integrity of the graft was similar between the inverted artificial chamber technique and the modified SCUBA technique (p=1.00). Macroscopic integrity was consider as grafts with tears smaller than 2 mm from the edge of the tissue after 8 mm trepanation. The artificial chamber that operates with the inverted cornea proved to be reproducible and suitable for endothelial graft preparation for the DMEK technique.
Velocidade de onda de pulso de 8,2m/s para identificação de biomarcadores em pacientes hipertensos
(Universidade Federal de Goiás, 2022-08-08) Inuzuka, Sayuri; Vitorino, Priscila Valverde de Oliveira; http://lattes.cnpq.br/1815619227221108; Souza, Weimar Kunz Sebba Barroso de; http://lattes.cnpq.br/6847019017274804; Souza, Weimar Kunz Sebba Barroso de; Brandão, Andrea Araújo; Miranda, Roberto Dischinger; Jardim, Paulo Cesar Brandão Veiga; Sousa, Ana Luiza Lima
Background: Which pulse wave velocity (PWV) value has the greatest association with biomarkers remains poorly understood. Objective: Identify from which pulse wave velocity (PWV) value, there is a greater possibility of identifying association with the presence of left ventricular hypertrophy (LVH), increased intima-media thickness (IMT) and presence of carotid plaque in hypertensive patients. Methods: This is a cross-sectional study of patients submitted to the measurement of central (oscillometric method) and peripheral blood pressure (automatic devices) parameters. Carried out between October / 2018 to March / 2019. ROC curves were constructed to estimate the discriminating power of the independent variables to identify the interquartile value of PWV association with biomarkers. The univariate logistic regression model was applied to identify the probability of TOD according to the different scores and to establish sensitivity and specificity of each predictor. The analyses were performed considering the significance level of 0.05. Results: 119 patients were evaluated. The mean age was 60.38 years (± 10.31) and 69,75% were women. An analysis of the sensitivity and specificity (ROC curve) of each biomarker IMT, LVMI and carotid plaque was performed at the cut-off points corresponding to the PWV 8.1, 8.2 and 8.7 m/s of the sample. PWV above 8.2ms was associated with increased IMT (p = 0.004), with the presence of carotid plaque (p = 0.003) and with left ventricular hypertrophy (LVH) (p<0.001). PWV above 8.2 showed greater sensitivity for IMT (AUC = 0.678, sensitivity 62.2), LVH (AUC = 0.717, sensitivity 87.2) and presence of plaque (AUC = 0.649, sensitivity 74.51) in the ROC curve. Conclusion: The 8.2m/s value is more sensitive in identifying the existence of increased IMT, presence of carotid plaque and LVH prematurely. These findings may indicate which value of PWV would be ideal for classifying as normal values.
Avaliação clínica e molecular do efeito do laser de baixa potência no controle da mucosite oral radio e quimioinduzida em pacientes com câncer na região de cabeça e pescoço: ensaio clínico randomizado
(Universidade Federal de Goiás, 2014) Leite, Angélica Ferreira Oton; Mendonça, Elismauro Francisco de; Batista, Aline Carvalho; Silva, Tarcília Aparecida; Alves, Fábio de Abreu; Celes, Mara Rúbia Nunes; Oliveira, José Carlos de; Rotta, Rejane Faria Ribeiro
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Desenvolvimento do raciocínio clínico em estudantes de medicina do primeiro ao quinto ano
(Universidade Federal de Goiás, 2015-02-03) Roberti, Alexandre; Pereira, Edna Regina Silva; Costa, Nilce Maria da Silva Campos; Costa, Nilce Maria da Silva Campos; Amaral, Eliana do; Porto, Celmo Celeno; Lima, Fátima Maria Lindoso da Silva; Taleb, Alexandre Chater
INTRODUCTION: There is a partial understanding of the clinical reasoning development. The SCT usage is not common in Brazil. OBJECTIVES: We aimed to analyze the clinical reasoning development and the SCT application in a medical school of a brazilian university. METHODS: analytical, descriptive research, quantitative/qualitative with SCT and focus groups. The test had ten clinical cases in Internal Medicine, which has been accomplished with reference panel. The study has five focus groups, eight of each year, from first to fifth year. RESULTS: Participated 159/550 academics in the SCT. In SCT preclinical phase the average was 51.6% and clinical phase 63.4% of the maximum. We found significant difference (40%) of study items. Cronbach's Alpha of 0,64. Participated 40/159 academics in focus groups. The content of the speech was divided into clinical reasoning and knowledge of the basic disciplines. DISCUSSION: In the SCT senior performed better. The construction of SCT is not easy. The low reliability because: problems in construction, panel limitations and punctuation key. In preclinical phase reasoning is based on the basic disciplines and clinical phase pattern recognition. 80.6% perceived use of basic disciplines. CONCLUSION: In the pre-clinical phase, the reasoning is dependent on the basic disciplines and clinical phase pattern recognition. The SCT is a difficult application instrument.
Avaliação do tempo de trânsito orocecal e do teste de tolerância à glicose em pacientes chagasicos e não chagasicos com ou sem constipação intestinal
(Universidade Federal de Goiás, 2014-06-10) Bafutto, Mauro; Oliveira, Ênio Chaves de; Oliveira, Ênio Chaves de; Rezende Filho, Joffre; Alves Neto, Onofre; Silva, Nilsio Antônio da; Ramos, Gilson Cassen
Background : Most patients with chagasic megacolon presents constipation. However in about one third of patients, despite the megacolon, bowel habits are normal.On the other hand, Chagasic patients may show constipation without evidence of colonic involvement.Thus, the determining factors of constipation in Chagas disease, are not completely understood. The question then arises: if it's not the megacolon solely responsible for constipation, what other factors are involved? In an attempt to answer this question, we evaluated the possibility of involvement not only of the colon, but also of the small intestine, very important organ in the absorption of nutrients and the formation of fecal bolus. This study evaluated whether there is change on orocecal transit and glucose absorption in the small intestine of Chagasic patients and non Chagasic with or without constipation by orocecal transit time measurement and the oral glucose tolerance test. Methods :Six groups of patients were studied: 1) – control group-Without constipation without megacolon and negative for Chagas disease serology; 2)-With constipation without megacolon and negative serology for Chagas disease; 3)-With constipation without megacolon and positive serology for Chagas disease; 4)-Without constipation without megacolon and positive serology for Chagas disease, 5)-With constipation with megacolon and positive serology for Chagas disease. 6)-Without constipationwith megacolon and positive serology for Chagas disease. For measurement of the orocecal transit time was used the H2 expired test. Results : It was observed a great extension of this time in the Group of patients with chagasic megacolon and constipation, which was statistically significant (p=0,001) when compared to all the other groups studied. It was observed that this time is greater in constipated than not constipated (p=0,005). The oral glucose tolerance test used in the evaluation of glycemic curve, showed that blood glucose levels were lower in Chagas disease patients, with statistically significant difference in relation to patients with Chagasic constipation and/or megacolon at 30 (p=0,003),60(p=0,005) e 90 minutes (p=0,001). It was interesting to note that patients with constipation and megacolon, were the only ones among all groups, which showed statistically significant difference at the same time both for the glucose tolerance test as to orocecal transit time. In conclusion, Chagasic patients with constipation and megacolon the orocecal transit time is delayed and during glucose tolerance test present highest rates of blood glucose.These data can correspond to a dysfunction of peristalsis and glucose absorption in the small intestine in patients with Chaga´s disease presenting with megacolon and constipation.
Desenvolvimento, caracterização e avaliação da atividade antiproliferativa de paclitaxel e rapamicina em lipossomas alvo-específicos contra células de câncer de mama HER2-positivas
(Universidade Federal de Goiás, 2012-04-23) Ferreira, Fabrícia Saba; Lima, Eliana Martins; Freitas Junior, Ruffo de; Magalhães, Nereide Stela Santos; Oliveira, Anselmo Gomes de; Amaral, André Corrêa
Liposomes are vesicles in which one or more phospholipid bilayers enclose an inner aqueous compartment. Liposomes may be designed as drug delivery systems for either hydrophilic and lipophilic drugs, also, surface modifications can promote active targeting of the drug carrier to the pharmacologic target site. Immunoliposomes are prepared with antibodies on their surface used for active targeting. Overexpression of the human epidermal growth factor receptor 2 (HER2) occurs in 20-35% of breast cancer. Trastuzumab (anti-HER 2) is a humanized monoclonal antibody designed to specifically antagonize HER’s function. Paclitaxel is a potent drug used against solid tumors including ovarian carcinoma and metastatic breast cancer. Rapamycin is a lipophilic macrolide antibiotic developed as an immunosuppressant and was subsequently found to display potent antitumour activity in a variety of solid tumors. In this work, the encapsulation of rapamycin and paclitaxel in liposomes and immunolipossomes was investigated to evaluate the antiproliferative efficiency of these drugs using the monoclonal antibody (trastuzumab) which targets HER2 receptors present in breast cancer cells (SKBR3). Smalls liposomes with mean diameter of about 100 nm were prepared by lipid film hydratation, followed by extrusion. Immunoliposomes were produced by covalently linking thiolated trastuzumab to DSPE-PEG(2000)-maleimide followed by its insertion into pre-formed liposomes. Co-encapsulation of paclitaxel and rapamycin in liposomes and immunoliposomes was successfully obtained. These systems were more cytotoxic to tumor cells than liposomes containing one of the drugs. Approximately 12 anti-HER2 antibody units were covalently coupled to each liposomal surface. Immnuliposomes showed higher citotoxicity in comparison to liposomes without antibody in their surface. The inhibitory concentrations 50% (IC50) of paclitaxel and rapamycin encapsulated in immunolipossomes was, respectively, 71% and 80% lower than non-targeted liposomes after 48 hours of incubation Fluorescence microscopy demonstrated that immunoliposomes (labeled with rhodamine) were able to interact with the surface of SKBR3 cells. The imunoliposomes represent a promising drug delivery system to improve the efficacy of co-encapsulated paclitaxel and rapamycin using the active targeting approach.
Efeito da eletroacupuntura no tratamento de pacientes adultos com osteoartrite primária de joelho: revisão sistemática com metanálise
(Universidade Federal de Goiás, 2024-04-12) Cruz, Virgínia Barbeitos; Sousa, Ana Luiza Lima; http://lattes.cnpq.br/6578713509935374; Sousa, Ana Luiza Lima; Batista, Sandro Rogério Rodrigues; Andrade, Jerusa Alecrim; Tarragó, Maria da Graça Lopes; Botelho, Leonardo Monteiro
Background: Osteoarthritis (OA) is the most prevalent joint disease in the world, causing pain, rigidity, and functional limitation of adults over 45 years. Objective: We conducted a systematic review to synthesize the results of clinical randomized studies to measure the effectiveness of electroacupuncture (EA) in the management of pain and articular dysfunction in adults with primary knee OA, Kellgren-Lawrence grades 2 and 3. Methods: Two independent reviewers searched for interventional clinical studies on the effectiveness of EA published on PubMed, Embase, Scopus, and Web of Science databases between January 2001 and January 2024. The statistical analysis focused on the effect size. Data summarization was performed through specific meta-analyses for the outcomes of interest. For statistical analysis, R software version 4.3.2 was used. The quality of the studies was assessed according to Critical Appraisal Skills Programme (CASP) and Revised STandards for Reporting Interventions in Clinical Trials of Acupuncture (STRICTA). Results: Three out of 7,428 articles were eligible. Meta-analysis showed no effect of EA on the attenuation of pain and joint dysfunction in primary knee OA [2.67 standardized mean difference (SMD); -9.86; 4.52, p = 0.249] and functional limitation (-2.02 SMD -6.86; 2.83 p = 0.215), p < 0.01. We observed compliance with STRICTA of 72.7% at 58.5%, with moderate risk (54.5% and 63.6%) or low risk of bias (90.9%) in CASP. Conclusion: In the meta-analysis, we identified that EA is not effective in treating pain and joint impairment in patients with primary knee OA. Trial registration: International Prospective Register of Systematic Reviews (PROSPERO) CRD42023469183 (https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=469183).
Percepção da qualidade de vida de acadêmicos e de professores de educação física em inicio de carreira
(Universidade Federal de Goiás, 2023-06-01) Souza, Lídia Acyole de; Barbosa, Maria Alves; http://lattes.cnpq.br/5025797873585225; Barbosa, Maria Alves; Brasil, Virgínia Visconde; Ferreira, Pedro Augusto de Melo Lopes; Rechenchosky, Leandro; Póvoa, Thaís Inácio Rolim
Introduction: Quality of life (QOL) is an important indicator of population health, and covers the inspection of different areas of a person's life. The process of formation and insertion in the labor market is characterized by change and uncertainty, and therefore the importance of studying QoL in this period. The aim of this study is to evaluate QoL in the academic training and beginning pysical education teachers (PET) career Methodology: The field research was transversal, quantitative, with academics and graduates of Physical Education at a University in Goiás. The sample was probabilistic by clusters and occurred in 2019. A sociodemographic form and the WHOQOL BREF questionnaire were used to assess QOL. The SPSS package was used and the significance value was set at 5%. Results: There were 330 participants, where 246 (74.5%) were academics and 84 (25.4%) were teachers. In general, lows were more frequent in women in Domino Social (OR: 1.93; p = 0.005) and general QOL (OR: 1.63; p = 0.030); Academics had higher chances of scores up to 33.3 in the Psychological Domain in relation to professors (OR: 11.1; p = 0.002), and each year unit, increased the chance of lower scores in the psychological domain (OR: 0.94 ; p = 0.0039). Conclusion: Women had low perceptions in the social domain and QOL, and increasing age showed higher scores in the psychological domain. In female undergraduates, it was associated with low scores in QOL domains, however, at the beginning of the Physical Education Teacher's career, time since training in the area of expertise contributed to worse results in the social, psychological and QVG domains. In the association between academics and early-career professors, academics were worse in the field of psychology.
Detecção do papilomavírus humano e análise de P16ink4a em carcinomas colorretais
(Universidade Federal de Goiás, 2021-03-26) Libera, Larisse Silva Dalla; Saddi, Vera Aparecida; http://lattes.cnpq.br/7496804650895441; Saddi, Vera Aparecida; Silva, Antônio Márcio Teodoro Cordeiro; Carneiro, Megmar Aparecida dos Santos; Guillo, Lidia Andreu; Mrué, Fátima
Introduction: Colorectal cancer (CRC) is one of the most prevalent cancers, being the second leading cause of cancer death worldwide. Despite the well established role of human papillomavirus (HPV) in anal cancer, its involvement in colon and rectum tumors is still a controversial issue. Objective: To investigate the presence of HPV and the expression of p16INK4a in colorectal carcinomas and in non-tumor controls, and to describe the prevalence of HPV in colon, rectum and anal cancers through a literature review. Methodology: This is a retrospective observational study that used clinical and pathological data and paraffin embedded specimens from patients with and without colorectal carcinoma. HPV detection was accomplished by PCR, genotyping by reverse hybridization, and the expression of the cellular protein p16INK4a was investigated by immunohistochemistry. A systematic review was also carried out on the databases, PUBMED, LILACS and SCIELO, according to PRISMA recommendations. Results: HPV was detected in 13% of the cases and the most prevalent genotype was HPV 16. The virus was not detected in both control groups. A high expression of p16INK4A was observed in 30% of the cases, but it was not associated with the presence of HPV. The overall survival was 53.3% and it was influenced by the prognostic factors such as advanced staging, lymph node and distant metastasis. Regarding the literature review, data were collected from 42 studies (5,834 samples). HPV was detected in 88.9% of anal cancer cases, and in 10.9% of colorectal cancer cases. Genotypes 16 and 18 were the most prevalent in both tumors. HPV was associated with anal squamous cell carcinoma (p <0.0001) and more prevalent in women with anal cancer (p <0.0001). Conclusion: Our results demonstrate that HPV is unlikely to be involved in colorectal carcinogenesis, and that p16INK4a expression is not a relevant biomarker of transcriptionally active HPV infection in CCR. The literature review data reassures the HPV causal relationship in anal cancer, but not in colorectal cancer.
Teleducação enquanto estratégia para qualificação profissional: uma imersão no contexto do Telessaúde Goiás
(Universidade Federal de Goiás, 2024-08-27) Santana, Cristina Célia de Almeida Pereira; Taleb, Alexandre Chater; http://lattes.cnpq.br/3191620401627150; Taleb, Alexandre Chater; Naghettini , Alessandra Vitorino; Dornelas, Rodrigo Faria; Alves, Sergiane Bisinoto; Ferreira, Eric Benchimol
A assistência à saúde tem sido impulsionada por constante inovação e pela incorporação da tecnologia em seus processos de trabalho. Neste contexto, a telessaúde se traduz como um método de mediação entre os profissionais e o ato de cuidar com o intuito de instrumentalizar as atividades teórico-práticas para garantir maior acessibilidade, resolutividade e qualidade à assistência. Durante a Pandemia pela COVID-19, a telessaúde tornou-se um pilar essencial para o atendimento de demandas assistenciais e educativas na saúde. Dentre as suas diversas modalidades destacou-se a teleducação, pois seus recursos, direcionados primariamente para fomentar a educação permanente dos profissionais alocados no Sistema Único de Saúde (SUS), foram indispensáveis para manter processos formativo-acadêmicos, capacitar os profissionais de saúde e oportunizar informação à comunidade. Concebendo a relevância desta estratégia, o presente estudo objetivou conhecer o contexto da teleducação no Núcleo de Telemedicina e Telessaúde de Goiás (NUTTs-GO). Trata-se de uma pesquisa de campo, descritiva e exploratória com uma abordagem de escopo quanti-qualitativa. O desenvolvimento da pesquisa compreendeu três fases: a realização de uma revisão integrativa da literatura para contextualização da teleducação no Brasil; a análise do banco de dados de teleducação do NUTTs-GO e a realização de uma entrevista com profissionais da atenção básica, usuários da modalidade teleducação. Os resultados da revisão de literatura demonstraram que a teleducação como estratégia fortaleceu-se por suas inúmeras possibilidades e por sua incorporação na dinâmica da sociedade. Constatou-se que há uma contínua ampliação dos pontos de telessaúde para propiciar aos trabalhadores da saúde no SUS maior acessibilidade ou oportunidades a momentos para educação permanente. Entretanto, ainda há desafios a serem superados como a necessidade de melhorar a instrumentalização das unidades e mais apoio dos gestores para implementar a iniciativa. A análise do banco de dados das teleaulas do NUTTs-GO permitiu verificar a existência de diversidade temática, boa abrangência em sua xiv Resumo disponibilização e o envolvimento multidisciplinar em sua construção, critérios que fazem o Núcleo Telessaúde em Goiás estar alinhado aos pressupostos para fomentar a capacitação de profissionais lotados na Atenção Básica. A análise qualitativa das entrevistas, última etapa do estudo, identificou que os profissionais dos Estabelecimentos Assistenciais de Saúde validam positivamente o processo de educação permanente mediado pela modalidade teleducação. Os elementos identificados em suas percepções indicam que os recursos de teleducação têm colaborado para interação, troca de experiências e aprimoramento técnico-científico, o que contribui para agregar qualidade ao cuidado e para uma prática assistencial mais resolutiva e humanizada. Todavia, as falas dos participantes indicaram que, para promover o processo de aprendizado com significado, premissa da educação permanente em saúde, os recursos de teleducação devem ser elaborados a partir da abordagem de problemas ou situações vivenciadas na prática laboral, ou de demandas de saúde locorregionais. Este alinhamento pode estimular a melhor reflexão crítica e a busca por melhorias efetivas nos processos de trabalho. Conclui-se que a imersão, no contexto da modalidade de teleducação no NUTTs-GO, permitiu vislumbrar uma dimensão importante da telessaúde. Como estratégia educativa, a teleducação alia recursos tecnodigitais para estender aos profissionais na atenção primária, mais conhecimento, consultoria e interatividade com os grandes centros e Universidades. Considerou-se que o Núcleo de Telessaúde em Goiás tem colaborado de maneira assertiva e proativa na formação de vínculos para implementar o processo de educação permanente dos profissionais da Atenção Básica no estado, movimento que vem ao encontro da Política Nacional de Educação Permanente para adjuvar o fortalecimento do SUS.
Avaliação da instalação de implantes dentários em mandíbula por meio de navegação dinâmica utilizando um novo software de tomografia computadorizada de feixe cônico
(Universidade Federal de Goiás, 2024-07-16) Garrote, Marcel da Silva; Estrela, Carlos; http://lattes.cnpq.br/3611967334176683; Alencar, Ana Helena Gonçalves de; http://lattes.cnpq.br/2039898015468283; Alencar, Ana Helena Gonçalves de; Estrela, Cynthia Rodrigues de Araújo; Serpa, Giulliano Caixeta; Silva, Julio Almeida; Decurcio, Daniel de Almeida
Introduction: Contemporary dentistry has been gradually adjusting to the changing needs and technological e-Volution of this field of health, and the use of modern techniques, with more advanced appliances, is essential in treatments with dental implants in the mandible, as in the case of the use of new cone beam computed tomography software, capable of dynamically navigating. contributing to the greater success of this type of procedure. Objectives: Evaluate Jaw Dental Implant Placement Through Dynamic Navigation Using Novel Cone Beam CT Scan Software. Methods: The initial sample consisted of 2,872 cone beam computed tomography scans of patients of both sexes aged between 18 and 80 years. The criteria used to evaluate the installation of dental implants were: location of the implants in the mandible; implant length; anatomical relationship with the mandibular canal; presence or absence of damage to the teeth adjacent to the implant; presence or absence of implant fracture; presence or absence of bone support for the implant. Categorical variables were described as frequencies and percentages and evaluated using the chi-square test. The level of significance was set at p <0.05. Statistical analysis was performed using the Statistical Package for the Social Sciences, version 20. Results: From the initial sample of 2,872 CBCT exams, 214 images of patients of both sexes and with a mean age of 44.5 years were included in the present study. The most frequent positioning of implants was in the posterior region of the mandible (93.5%), with 54.0% having a length between 9 and 14mm. It was found that 92.0% were located above the mandibular canal, and there were no records of implants inside the mandibular canal. There was no statistically significant relationship between implant length and mandibular canal invasion (p=0.357). Three cases of damage to adjacent teeth were observed, with no correlation with implant positioning (p=0.999). No correlation was observed between age group and damage to adjacent teeth (p=0.999). In 100.0% of cases of anterior implants there was the presence of bone support, and in 91.6% of posterior implants, no statistically significant difference was observed between them (p=0.614). There was no statistically significant difference between age groups regarding the presence of bone support (p=0.254). Although fractures were observed (1.7%) in implants with lengths between 9mm and 14mm, there was no statistically significant relationship between implant length and fracture (p=0.702). Conclusion: Dynamic navigation using e-VolDX allowed us to conclude that the installation of implants in the mandible occurred more frequently in the posterior region, in the presence of bone support and with a low percentage of damage to adjacent teeth, anatomical structures and fractures
Autopercepção da saúde e da qualidade de vida, desempenho funcional e prática de atividade física entre idosos residentes em município rural no interior do Brasil
(Universidade Federal de Goiás, 2021-07-16) Barbosa, Renata da Costa; Sousa, Ana Luiza Lima; http://lattes.cnpq.br/6578713509935374; Sousa, Ana Luiza Lima; Souza, Weimar Kunz Sebba Barroso de; Batista, Sandro Rogério Rodrigues; Zanini, Claudia Regina de Oliveira; Leite, Márcia Andréa Gonçalves
Aging can lead to greater dependence on the individual, compromising functional performance, self-perception of health and quality of life. A physically active lifestyle can provide the maintenance of functionality and improve the quality of life and health of the elderly. Behavior and lifestyle habits may be influenced by the location where the elderly person lives. Understanding how elderly people living in rural municipalities perceive their health and quality of life can provide subsidies to better help these populations. Objective: To analyze the associations between self-perceived health and quality of life with functional performance and the practice of physical activity among elderly people living in rural municipality in Brazil. Method: Analytical cross-sectional population-based study. Individuals aged 60 years or more, noninstitutionalized, living in a rural municipality in the interior of Goiás were included. Sociodemographic, anthropometric and lifestyle variables were evaluated. In addition, functional performance was assessed using the Timed Up and Go (TUG) test and physical activity practice using the International Physical Activity Questionnaire (IPAQ). As outcome variables, self-perceived health and quality of life were assessed using the Bref and Old World Health Organization Quality of Life Instruments questionnaires (WHOQOL BREF and WHOQOL OLD). Data were obtained during a home visit, by an interview. To assess the association of the variables of interest, Pearson's chi-square test, Fisher's exact test and the Wilcoxon sign were used. Results: The study included 142 elderly people with a mean age of 72.4 (±8.0) years. More than half were classified as sufficiently active (66.9%), among these, 55.8% performed leisure activities, the vast majority were independent in activities of daily living (87.3%), with regular/good quality of life (average overall score: 3.6±0.3) and, respectively, 57.7% and 64.1% had self-perceived health and quality of life. Elderly people with poor or very poor self-perceived health had regular self-perceived quality of life (63.6%), individuals aged 80 years and over had lower self-perception of quality of life compared to others. There was an association of self-rated health with the practice of physical activity and functional performance. However, no associations were found with the type of physical activity. It was found that 50.0% of the elderly who were insufficiently xvii Abstract 18 active and independent perceived their health positively. Of the insufficiently active and dependent elderly, 35.7% had poor/very bad and good/very good self-perceived health. Conclusions: Elderly people living in a rural municipality showed good or very good perception of health and quality of life, independent in their activities of daily living and sufficiently active. Self-perceived health was associated with quality of life, functional performance and physical activity practice, not being associated with the other study variables.
Pseudodemência depressiva: fenomenologia psicopatológica e disfunções cognitivas
(Universidade Federal de Goiás, 2019-11-22) Reimer, Cláudio Henrique Ribeiro; Caixeta, Leonardo Ferreira; http://lattes.cnpq.br/9536747113677509; Caixeta, Leonardo Ferreira; Azevedo, Paulo Verlaine Borges e; Vieira, Renata Teles; Nascimento, Eberson da Silva Rodrigues; Taveira, Daniela Londe
Depressed patients often present cognitive impairment, including the possibility of developing dementia - called Depressive Pseudodementia. Despite the seriousness of the disease, publications with case presentation and psychopathological discussion are scarce. Objectives: To describe demographic, clinical and cognitive aspects in a group of patients with depressive Pseudodementia, besides reporting possible associations between Pseudodementia and the observed clinical findings. To perform a review on the topic and discuss the relevance and validity of the diagnosis. Methods: This is a descriptive study composed of patients with Pseudodementia Depressiva treated in Goiás in the 2007-2017 period, presenting a discussion about the results and comparison with other studies through literature review. Multidimensional anamnesis was used for the collection of clinical history and pathological antecedents. The diagnosis of Depressive Pseudodementia was performed by Yousef pseudodementia scale (YPS); other psychiatric diagnoses were defined by the DSM-5 and the severity of depression by the Hamilton scale. The cognitive assessment was performed by the Mini-Mental State Examination, functional questionnaire of Pfeffer and Clinical Dementia Rating (CDR). Results: The sample consisted mainly of women (96.67%) with a history of cardiovascular disease (43.33%) and neurological signs (53.33%). Depression with melancholic features occurred in 56,66% of the cases and the diagnosis of Bipolar Mood Disorder occurred in 100% of the sample. The main cognitive dysfunctions found were inattention (100%) and short-term hypomnesia (93.33%) corroborating the findings of the literature related to cognitive impairment and depression. Conclusions: The demographic and clinical aspects associated with Depressive Pseudo-dementia were female, antecedent of cardiovascular disease and presence of neurological signs; the basic psychiatric diagnosis was Bipolar Mood Disorder and the dominant depressive phenotype was depression with melancholic characteristics; and the central cognitive impairment was attention and short-term memory.
Perfil clínico, epidemiológico e molecular de crianças hospitalizadas em Centros Hospitalares de Goiânia-GO com Infecções Respiratórias Agudas (IRA) causadas pelos vírus Influenza A e B e seus subtipos
(Universidade Federal de Goiás, 2022-10-13) Silva, Paulo Alex Neves da; Avelino, Melissa Ameloti Gomes; http://lattes.cnpq.br/0519039948275501; Carneiro, Lilian Carla; http://lattes.cnpq.br/6506744224041777; Carneiro, Lilian Carla; Byk, Jonas; Wastowski, Isabela Jubé; Pires, Debora de Jesus; Costa, Paulo Sérgio Sucasas da
Acute respiratory infections (ARI) are the largest group of diseases with prevalence in children and were included among the three main public health problems of childhood in the late 1960s. The high rate of morbidity makes ARI the main cause of use of health services, representing 20 to 40% of consultations in pediatric services worldwide and 12 to 35% of hospital admissions. Among the main causes of infections, bacterial, fungal and viral infections can be mentioned and according to the World Health Organization, approximately 90% of respiratory infections in children are of viral origin. Given the above, the objectives of the study were to evaluate the epidemiological and molecular profile of acute respiratory infections caused by influenza A and B viruses and their subtypes in children in Hospital Centers in Goiânia-GO. All children with acute respiratory symptoms who were treated in the Emergency Department and/or were admitted to Pediatric wards and/or ICUs were included. Our results corroborate the data that indicate that Rhinovirus, Adenovirus, Metapneumovirus and Influenza are among the most important AKI agents in pediatrics. As for influenza viruses, most patients were asymptomatic, however, some patients had symptoms such as fever and cough. Most of the infected were female. Knowing the epidemic period of respiratory infections observed in Goiânia can be useful to plan and implement prevention strategies.
Transmissão sexual do Trypanosoma cruzi em humanos: uma revisão de escopo associada a um estudo observacional
(Universidade Federal de Goiás, 2024-08-26) Costa, Marillia Lima; Lacerda, Elisângela de Paula Silveira; Zapata, Marco Tulio Antonio Garcia; http://lattes.cnpq.br/3672512339058369; Zapata, Marco Tulio Antonio Garcia; Teixeira, Antônio Raimundo Lima Cruz; Silva, Hugo Delleon da; Anunciação, Carlos Eduardo; Cardoso, Clever Gomes
Introduction: The possibility of sexual transmission of Trypanosoma cruzi was suggested by Carlos Chagas after the discovery of the disease. However, the infectivity of semen samples and sexual transmission of the parasite on animal models occurred recently with few studies evaluating this transmission mechanism in humans. Objectives: to investigate the possibility of sexual transmission of trypanosomatids and T. cruzi, both in experimental animals and human. Methods: a scopimg review associated with an observational study was conducted. The search for studies was performed in the databases PubMed, Lilacs, Global Health and Portal CAPES with the following terms: “Trypanosomids”, “Trypanosoma”, “Leishmania”, “Sexual Transmission”, “Sêmen”, “Vaginal Secretion”, “Male”, “Female”, in English, Spanish and Portuguese. An observational study was also conducted to investigate the sexual transmission of T. cruzi in a population of 171 individuals distributed across 10 families residing in the municipality of São Felipe, Bahia. Blood and semen samples obtained were analyzed by serological and molecular methods, combined with socio-epidemiological information obtained from a questionnaire, in order to confirm or exclude the sexual transmission of T. cruzi. Results: According to the eligibility criteria 27 articles were found. Literature reports showed the presence of protozoa of Leishmania and Trypanosoma genus in reproductive organs and sexual fluids, as well as the sexual transmission of these parasites to sexual partners and offspring. In the observational study, the presence of T. cruzi in blood samples was found in 24,56% through molecular testing. Epidemiological analysis indicated that the infected group consisted predominantly of women, aged 20 to 50 years, married, self-identified as black, rural workers, born in the rural areas of the municipality, with low socioeconomic status and educational level. Analysis of semen samples revealed the protozoan in only one semen samples, with the presence confirmed by sequencing technique. The association of molecular findings from blood and semen analyses and information extracted from the applied questionnaire identified at least three cases of women who acquired the infection through sexual transmission. Conclusion: based on the information obtained from the review, as well as the presence of T. cruzi in semen samples, it was possible to conclude that trypanosomatids, especially T. cruzi, can be sexually transmitted, with semen being an infective fluid
Qualidade de vida dos demandantes de medicamentos oncológicos nas vias administrativa e judicial em Goiás
(Universidade Federal de Goiás, 2022-10-16) Salha , Leila Abou; Barbosa, Maria Alves; http://lattes.cnpq.br/5025797873585225; Barbosa, Maria Alves; Brasil, Virgínia Visconde; Mendonça, Reginaldo Teixeira; Ferreira, Pedro Lopes; Féres, Valéria Christina de Rezende
Background: The significant increase in access to oncological medicines through court cases suggests that constitutional guarantees of integral and universal care in the Brazilian public health system are uncertain. Methods: A retrospective observational study was conducted to analyze data from lawsuits requesting oncological medicines from 2014 to 2020 in the State of Goiás, Brazil, in state and federal courts. Sociodemographic, medical, and legal variables were statistically examined using descriptive, association, and correlation methods. Results: Women brought more than half (54%) of the 301 processes analyzed. The most frequent age group was over 55 years, with income below 3x the minimum wage (total about USD$600/month), and their cases were promoted through the public minister and public defender’s offices. The most requested medications, not on official public health system lists, were indicated for multiple myeloma and brain cancer. Conclusions: Improved quality of life, frequently used as a justification, could be conceptually confused with an increase in survival. Finally, judicialization indicates that individual health needs arise even with properly defined and adequately implemented public policies. These needs should be considered for the adequate provisioning of services by the state to ensure the right to health.

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