Retinol sérico, proteína ligante de retinol (RBP-4) e fatores de risco cardiometabólicos em crianças de 4 a 11 anos de idade
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2020-02-06
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Universidade Federal de Goiás
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Based on the hypothesis that children choose dyslipidemia, they present alterations in American retinol samples known as fat-soluble vitamins and antioxidants and that these variations can be used as cardiovascular risk. Therefore, the objectives of this study were to investigate the associations / influences of serum retinol and retinol binding protein (RBP-4) concentrations on risk factors and the cardiometabolic association. The study population included 212 children recruited from a public school in the city of Santo Antônio-Goiás for the study of serum retinol, and 36 were randomly selected for the RBP-4 study. The survey was conducted in 2018 and 2019. Height, body mass, waist circumference, blood pressure, lipoproteins and retinol serum were evaluated. Serum retinol concentrations were analyzed by high performance liquid chromatography. Regarding the correlation of retinol concentration with anthropometric variables, blood pressure and lipid profile, there was a positive association, cholesterol (r=0.25 p=0.001) and LDL (r=0.20 p=0.002). Logistic regression analysis with adjusted cholesterol found an association of retinol only in the group with hypercholesterolemia (β= -0.02) (p=0.015). In the comparative analysis it was observed that the 212 children with hypercholesterolemia had higher serum LDL-c concentrations (p< 0.001) total cholesterol (p< 0.001) retinol (p=0.020) e HDL-c (p=0.040). The results obtained from 36 children drawn showed similar dietary intake among those who had adequate cholesterol and hypercholesterolemia. In children with hypercholesterolemia, a positive association of RBP-4 with lipids was observed (p=0,049) and retinol (p= 0,013). Through multiple linear regression, it was found that for each 1g of lipid ingested, there was an increase of de 0.08 µmol/L de RBP-4 (β= 0.088 p=0.041) and for every 1 µmol / L retinol in the blood there is a 55.50 µmol / L increase in circulating RBP-4 (β= 55.50 p=0.0009). Conclusion: Children with hypercholesterolemia have cardiometabolic risk factors associated with serum retinol concentration and elevated RBP-4. Also, in children with hypercholesterolemia, RBP-4 was associated with retinol and dietary lipids.
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TRINDADE , N. R. Retinol sérico, proteína ligante de retinol (RBP-4) e fatores de risco cardiometabólicos em crianças de 4 a 11 anos de idade. 2020. 100 f. Tese (Doutorado em Ciências da Saúde) - Universidade Federal de Goiás, Goiânia, 2020.