Investigação molecular de vírus em crianças com infecção do trato respiratório e crianças asmáticas em Goiânia-Goiás
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2015-04-23
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Universidade Federal de Goiás
Resumo
Acute respiratory infection (ARI) is a major cause of morbity and mortality worldwide,
particularly among children, and most of these infections are caused by viruses. Respiratory
viral infections can cause symptoms ranging cough, coryza, sneezing, fever and airflow
obstruction. Furthermore, the infection poses as an important trigger of asthma exacerbation,
frequent clinical condition in children, and its prevalence has been rising in the last years. There
are few epidemiologic studies analyzing the relationship between ARIs and asthma in Brazil.
Based on this background, the aim of the study was investigate the occurrence of viral
respiratory infections in pediatric patients with and without asthma in Goiânia – Goiás. Between
august, 2012 and august, 2013 225 nasal aspirates and/or nasal swab samples were obtained
from children with four to 14 years old. The samples were screened by Multiplex Nested-PCR
for detection of 16 common respiratory viruses. From 225 samples, 42 had at least one virus
detected. Samples from four different patients had more than one virus detected. The viral
detection rate in ARI patients (25%), exacerbated asthma (16.3%) and stable asthma (14.8%)
showed no significant difference. The most frequent viruses detected were Rhinovirus (28.6%),
FLUA (11.9%), Adenovirus (11.9%), HBoV (11.9%) and RSVA (9.5%). The monthly
detection rate was higher during the rainy season, period marked by great rainfall and high
relative air humidity. Among the positive samples, RSV were detected during the great rainfall
months and high air humidity, while the FLU and HBoV were detected during the winter
months, period with low air humidity in the Mid-West region. The seasonal profile from the
other viruses was unclear. The obtained results reinforces the importance of the viral pathogens
in the pediatric population. Although the viral detection rate was not statistically significant,
the presence of these pathogens in children is an important matter for consideration, especially
to delineate control and prevention measures concerning ARIs and its impact on preexistent
asthma. Hence, this study is the first of the kind in the region, and the data provided tried to fill
the knowledge gaps about seasonality and circulation of these pathogens.
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CASTRO, Í. A. Investigação molecular de vírus em crianças com infecção do trato respiratório e crianças asmáticas em Goiânia-Goiás. 2015. 77 f. Dissertação (Mestrado em Biologia da Relação Parasito-Hospedeiro) - Universidade Federal de Goiás, Goiânia, 2015