Aspectos epidemiológicos e genótipos do vírus da Hepatite C em caminhoneiros de rota longa do Brasil
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Data
2008-02-22
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Universidade Federal de Goiás
Resumo
Globally, the prevalence of hepatitis C virus (HCV) infection is about 3%, with a significant variation according to geographic areas and population groups. However, studies concerning this infection in truck drivers population are rare. This study aimed to determine the HCV infection prevalence, to analyse
associated risk factors and also to identify this virus genotypes in a population of long distance truck drivers in Brazil. In 2005-2006, 641 truck drivers who were circulating on BR-153 Federal road were interviewed and blood samples
collected. Blood samples (sera) were tested for anti-HCV antibodies detection by enzyme linked immunosorbent assay. Anti-HCV reactive sera were retested for confirmation by immunoblot and also for HCV RNA detection by polymerase
chain reaction. HCV RNA positive samples were genotyped by line probe assay (LiPA). Nine samples were anti-HCV positive, resulting in a prevalence of 1.4% (95% CI: 0.7-2.7). By multivariate analysis, use of illicit drug and hepatitis
B virus seropositivity (anti-HBc marker) were risk factors for this infection. Genotyping of HCV RNA positive samples revealed the presence of genotypes 1 (37.5%), 2 (25.0%) and 3 (37.5%). The findings of this study indicate an
intermediate endemicity for HCV infection in truck drivers in Brazil, the relevance of drug use in the transmission of this agent and the circulation of genotypes 1, 2 and 3 in the studied population.
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FREITAS, Nara Rubia de. Epidemiological aspects and hepatitis c virus genotypes in long distance truck drivers in Brazil. 2008. 87 f. Dissertação (Mestrado em Medicina) - Universidade Federal de Goiás, Goiânia, 2008.