Eletroanálise aplicada a ensaios de compatibilidade e estabilidade de fármacos
Nenhuma Miniatura disponível
Data
2020-08-31
Autores
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade Federal de Goiás
Resumo
Introduction: The pharmaceutical industry faces a major challenge to improve the
solubility of some active ingredients. Carvedilol (CRV) is the drug of therapeutic choice in
cardiovascular diseases. CRV presents low water solubility and low bioavaliability. Several
researches were performed in order to increase the oral bioavailability, where selfemulsifying
appeared as viable alternatives. Objective: The objective of this work was to
evaluate interactions between CRV and its excipients, detecting the oxidative potential of
these substances, thus, providing predictive data for the oxidation that may affect the
stability and bioavailability of the drug system. Methodology: In the carbon pastes
preparation were used 70 mg (graphite) and 30 mg (oil). Six excipients, oleic acid, canola,
capmul, safflower, sesame and Plurol isoestearique. The following proportions were used
in the making of the paste: 30:0, 20:10, 15:15, 10:20 and 0:30 of liquid excipient (sample):
mineral oil (mg:mg) and 1.5:68.5, 3:67 and 7:63 of solid excipient (sample): graphite
(mg:mg). CRV was incorporated in the oil moiety for solubilization and after used in solidstate
analysis in the carbon paste. The techniques used were cyclic voltammetry,
differential pulse voltammetry and electrochemical impedance spectroscopy. Results and
Discussions: The Isostearique Plurol® was found to be electro-active in the studied
potential, however, this oil oxidizes in different potentials from CRV. The results show that
Isostearique Plurol®, liquid excipient, isoestearique acid and the solid excipient presented
the greatest variations of anodic potential and were considered the best excipients for the
CRV formulation. CRV presented higher stability at room temperature (25 ºC), whereas, it
presented higher stability at 50 ºC when mixed with 7% estearique acid. Conclusions:
Evidences of incompatibility were not found, relative to the increase of oxidation
vulnerability, when in the presence of these excipients. The employment of electroanalysis
for CRV compatibility studies show promising viability.
Descrição
Palavras-chave
Citação
Carvalho, M. F. Eletroanálise aplicada a ensaios de compatibilidade e estabilidade de fármacos. 2020. 43 f. Tese (Doutorado em Ciências Farmacêuticas) - Universidade Federal de Goiás, Goiânia, 2020.