Análise de resistência a antimicrobianos de cepas de Mycobacterium tuberculosis isoladas no Estado de Goiás
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Data
2010-12-07
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Universidade Federal de Goiás
Resumo
Tuberculosis (TB) is a serious global public health. In Brazil for the confirmed TB cases is recommended
a multi-drug therapy regimen which combines different drugs during at least 6 month. However, because
of treatment inconsistency, the emergency and spread of drug resistant M. tuberculosis become a serious
threat. Actually, strains resistant to at least one drug used in the TB treatment have been one of the main
factor that avoid the effective TB control. According to WHO M. tuberculosis strains that are resistant to
at least INH and RMP, the key drugs used in the TB treatment, are considered multidrug resistant (MDRTB).
The main mutations responsible for INH and RMP resistance occur at some specific regions in the
katG, inhA and rpoB genes. We analyzed by phenotypic and genotypic methods the susceptibility profile
of M. tuberculosis isolated from 132 patients treated at a reference hospital in Goiânia-Goiás, between
January of 2006 and July of 2007 and then performed the resistant strains genotypic identifications by
RFLP-IS6110. Additionally, clinical and epidemiological informations from the patients was collected. A
high frequency of drug resistance was observed in previously untreated patients (13.6% to at least one
antibiotic and 6.1% MDR-TB), and a high DNA polymorphism was observed among these strains. Our
results suggest that the prevalence of resistant TB in Goiás is underestimated and that resistance in new
TB cases was not associated with an outbreak in this region.
Descrição
Citação
SANTOS, Lorena Cristina. Analysis of antimicrobial resistance of strains
Mycobacterium tuberculosis strains isolated in the State of Goiás. 2010. 74 f. Tese (Doutorado em Ciências da Saúde) - Universidade Federal de Goiás, Goiânia, 2010.