Avaliação da produção de citocinas, quimiocinas e fatores de crescimento nas fases aguda e convalescente da infecção pelo vírus Zika em área endêmica
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2017-12-05
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Universidade Federal de Goiás
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The Zika virus (ZIKV) is transmitted by the bite of the mosquito, mainly of the genus Aedes. The virus was first
isolated in nonhuman primates in Zika forest in Uganda in 1947. Between 1953-2006, there were sporadic cases of
ZIKV infection in humans in Africa, Asia and Oceania, and it was considered benign. In 2007, there was the first
outbreak of the ZIKV and from that time, began to emerge complications such as microcephaly and Guillain-Barre
syndrome. Approximately 80% of ZIKV infection cases are asymptomatic, but when symptoms do occur are usually
mild and nonspecific. The objective of this study was to evaluate plasma levels of cytokines, chemokines and growth
factors for infection ZIKV in acute and convalescente phases. Few immune mediators had significantly higher levels
in the acute phase, namely IFN-γ, IP-10 and RANTES when compared to healthy donors. In addition, plasma levels of
IP-10 were also significantly higher in the acute phase of infection when compared to the convalescent phase. No
associations were observed between cytokine, chemokines and growth factor levels that were evaluated, and the
number of symptoms or viremia. Together, our data indicate that the Zika virus infection during acute phase, in
endemic areas, is able to stimulate the immune system in a subtle way and with a markedly pro-inflammatory profile,
and it may not be able to eliminate the viral infection efficiently, collaborating for the immunopathogenesis of the
infection and favoring viral dissemination.
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SILVA, P. A. N. Avaliação da produção de citocinas, quimiocinas e fatores de crescimento nas fases aguda e convalescente da infecção pelo vírus Zika em área endêmica. 2017. 90 f. Dissertação (Mestrado em Biologia da Relação Parasito-Hospedeiro) - Universidade Federal de Goiás, Goiânia, 2017.