A medida da Fração Exalada do Óxido Nítrico (FeNO) como marcador do nível de controle da asma
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2016-11-16
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Universidade Federal de Goiás
Resumo
The main goal of asthma treatment is to achieve and maintain clinical control of the disease. The
exhaled fraction nitric oxide (FeNO) level is considered a biomarker of airways inflammation and
its important to conduct researches involving this measured and its relationship in evaluation of
asthma control.Objective: To determine whether the FeNO level can be used to discriminate
between patients with controlled, partially controlled and uncontrolled asthma. Materials and
methods: The FeNO level and asthma control were evaluated in a retrospective and analytic cross–
sectional study through data collected from asthmatic patients who were assessed by clinical
history, asthma control, physical examination, spirometry, and FeNO level. Asthma control was
determined by the criteria of the Global Initiative for Asthma, and classified as controlled asthma,
partially controlled asthma, and uncontrolled asthma. The FeNO values were classified as low
(<25 ppb) or intermediate/high (≥25 ppb), based on the American Thoracic Society
recommendations. Results: The symptoms of 81 asthmatic patients were classified as controlled
(34 [42%] patients), partially controlled (27 [33,3%] patients), and uncontrolled (20 [24.7%]
patients). The FeNO level discriminated between the uncontrolled and controlled groups (p = 0,01)
and between the uncontrolled and partially controlled groups (p = 0,01), but not between the
controlled and partially controlled groups (p = 0,98). An FeNO level >30 ppb was associated with
uncontrolled asthma (p < 0,01) with an area under the receiver operating characteristic curve of
0,78 (95% confidence interval, 0,65-0,89). Conclusions: The FeNO level aided the identification
of uncontrolled asthma. This measurement may can be helpful in determining asthma control.
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ABREU, F. C. A medida da Fração Exalada do Óxido Nítrico (FeNO) como marcador do nível de controle da asma. 2016. 78 f. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal de Goiás, Goiânia, 2016.