Ki-67, cd10, cd34, p53, cd117 e mastócitos no diagnóstico diferencial dos fibroadenomas celulares e na graduação dos tumores filóidesz

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dc.contributor.advisor1Moreira, Marise Amaral Rebouças
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/6390358577348486por
dc.contributor.referee1Moreira, Marise Amaral Rebouças
dc.contributor.referee2Paulinelli, Régis Resende
dc.contributor.referee3Deus, José Miguel
dc.contributor.referee4Finotti, Marta Curado Carvalho Franco
dc.creatorVilela, Maria Helena Tavares
dc.creator.Latteshttp://lattes.cnpq.br/7665249501645871por
dc.date.accessioned2014-09-30T19:29:06Z
dc.date.issued2013-10-09
dc.description.abstractThe proper management of breast phyllodes tumors (PTs) remains challenging, due to the difficulty of the correct preoperative diagnosis. The aim of this study was to evaluate the usefulness of the Ki-67, CD10, CD34, p53, CD117 and the number of mast cells for the differential diagnosis between benign PTs and cellular fibroadenomas (CFs), and also at the grading of PTs. 51 primary PTs and 14 FCs were examined by immunohistochemistry (IH). Through the evaluation of the expression of CD117, greater epithelial expression was found at the FCs and an increased number of mast cells in benign TFs. The stromal expression of the Ki-67, CD10, CD34 and p53 showed relevance to the grading of PTs.eng
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dc.description.resumoO manejo adequado dos tumores filóides (TFs) mamários continua desafiador, devido à dificuldade do diagnóstico pré-operatório correto. O objetivo deste estudo foi avaliar a utilidade do Ki-67, do CD34, do CD10, do CD117, da p53 e do número de mastócitos no diagnóstico diferencial entre os TFs benignos e fibroadenomas celulares (FCs), bem como na graduação dos TFs. Foram examinados 51 TFs primários e 14 FCs por imunohistoquímica (IH). Na marcação pelo CD117, houve maior expressão epitelial nos FCs e maior número de mastócitos nos TFs benignos. A expressão estromal do Ki-67, da p53, do CD10 e CD34 mostrou-se significante na graduação dosTFs.por
dc.formatapplication/pdf*
dc.identifier.citationVILELA, Maria Helena Tavares. Ki-67, cd10, cd34, p53, cd117 e mastócitos no diagnóstico diferencial dos fibroadenomas celulares e na graduação dos tumores filóides. 2013. 45 f. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal de Goiás, Goiânia, 2013.por
dc.identifier.urihttp://repositorio.bc.ufg.br/tede/handle/tede/3229
dc.languageporpor
dc.publisherUniversidade Federal de Goiáspor
dc.publisher.countryBrasilpor
dc.publisher.departmentFaculdade de Medicina - FM (RG)por
dc.publisher.initialsUFGpor
dc.publisher.programPrograma de Pós-graduação em Ciências da Saúde (FM)por
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dc.rightsAcesso Abertopor
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectTumores filóidespor
dc.subjectNeoplasias mamárias,por
dc.subjectProto-oncogene c- kitpor
dc.subjectKi-67por
dc.subjectP53por
dc.subjectCD34por
dc.subjectNeprilysinpor
dc.subjectMastócitospor
dc.subjectFibroadenomapor
dc.subjectPhyllodes tumorseng
dc.subjectBreast tumorseng
dc.subjectProto-oncogene c-kiteng
dc.subjectNeprilysineng
dc.subjectMast cellseng
dc.subjectFibroadenomaeng
dc.subject.cnpqMEDICINA::ANATOMIA PATOLOGICA E PATOLOGIA CLINICApor
dc.thumbnail.urlhttp://repositorio.bc.ufg.br/tede/retrieve/9090/Disserta%c3%a7%c3%a3o-%20Maria%20Helena%20Tavares%20Vilela-2013.pdf.jpg*
dc.titleKi-67, cd10, cd34, p53, cd117 e mastócitos no diagnóstico diferencial dos fibroadenomas celulares e na graduação dos tumores filóideszpor
dc.title.alternativeKi-67, cd10, cd34, p53, cd117 and mast cells in differential diagnosis of cellular fibroadenomas and in the classfication of phyllodes tumorseng
dc.typeDissertaçãopor

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Mestrado em Ciências da Saúde (FM)