Avaliação de erros de prescrição de medicamentos em unidades hospitalares da rede pública do Maranhão
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2014-12-17
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Universidade Federal de Goiás
Resumo
Background: Medication errors are a worldwide health problem. Actions to prevent prescription
errors and avoid damages are fundamental in the hospital environment, particularly in relation to
high-alert medications (HAM). There are few studies on the magnitude of prescription errors,
special considering HAM, in Brazil. Objectives: To estimate the prevalence of prescription errors
with an emphasis on potentially dangerous drugs and risk of drug interactions in all groups of
drugs in a hospital environment. Setting: It is a prevalence study, conducted in 10 public hospitals
at São Luís, a city located at the Northeast Brazil, in November 2012. Method: Prescriptions with
at least one medication were evaluated for legibility and omissions (dose, concentration, route of
administration, pharmaceutical form and diluents), according to parameters modified by DEAN B,
2000. MICROMEDEX 2.0 was used to evaluate drugs interaction. High-alert medication was
classified according to the Institute for Safe Medication Practices (ISMP). Results: Of a total,
1.020 prescription were evaluated, 91 (8.9%) were illegible. Excluding the illegible prescription,
929 had at least one omission error. Of a total, 1.431 HAM were prescribed. Among 618
prescriptions with ate least one HAM, 548 present at least one error, yielding a prevalence of
88.7% (IC 95% 86.2-91.2%). 1.089 prescriptions errors related to HAM were detected, resulting in
0.76 errors/prescription. Among 856 antibiotics prescribed, 92.7% had at least one omission error.
Among all prescription, 43.3% present, at least, one drug-drug interaction. A total 785 medication
interactions were detected: 12.2% mild; 47.9% moderate; 35.9% severe and 4.1% not indicated.
Conclusion: The results of this study disclose that prescribing HAM, antibiotics and prescription
errors associated with them are frequent in hospital settings. The results indicate the need of
pharmacoepidemiological surveillance activities to contribute to the rational use and patient safety
when subjected to pharmacotherapy.
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MORAES, Omar Khayyam Duarte do Nascimento. Avaliação de erros de prescrição de medicamentos em unidades hospitalares da rede pública do Maranhão. 2014. 154 f. Tese (Doutorado em Medicina Tropical e Saúde Publica) - Universidade Federal de Goiás, Goiânia, 2014.