Ácidos graxos ômega 3 na dieta de cães com doença valvar mitral
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2018-02-23
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Universidade Federal de Goiás
Resumo
Mitral valve disease (MVD) is characterized by thickening in the valvular leaflets and may lead
to heart failure. Pharmacological treatment of the disease with vasodilators, positive inotropes
and diuretics is used in conjunction with dietary management. Omega 3 (ω-3)
supplementation has been associated with modulation of blood pressure (BP) and heart rate,
improvement of Doppler echocardiography, antiarrhythmic, anti-inflammatory and
antidysiphyde effects. In the absence of prospective clinical studies, the objective was to
evaluate the influence of ω-3 supplementation in dogs with MVD. For this purpose, 41 dogs
were followed up every three months for 12 months by means of clinical evaluation, BP
measurement, electrocardiography, Doppler echocardiography, chest radiography, laboratory
tests, dosages of inflammatory mediators and cardiac biomarker. The dogs were classified in
stages B1, B2 and C, according to the ACVIM consensus. Dogs were randomly divided into the
ω-3 group, which received food for dogs with heart diseases supplemented with ω-3 and
control group (even food without supplementation). In stage B1 only dogs from the ω-3 group
were evaluated. At the end of 12 months, no changes were observed in the parameters
evaluated. In dogs stage B2 and C, there was an increase in the serum levels of inflammatory
mediators, in a larger amplitude in the control group. The ω-3 preserved body condition score,
muscle condition score and reduced by 2.96 times the chance of developing arrhythmias. The
DIVEdN and VHS measurements were higher in the control group and correlated with NTproBNP
cardiac biomarker concentrations. It is concluded that the supplementation with ω-3
in patients in classes B2 and C, maintains the body condition, helps reduce volume overload,
has an antiarrhythmic effect and keeps dogs with MVD in the firsts stages of the disease.
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NASCIUTTI, P. R. Ácidos graxos ômega 3 na dieta de cães com doença valvar mitral. 2018. 132 f. Tese (Doutorado em Ciência Animal) - Universidade Federal de Goiás, Goiânia, 2018.