Associação entre a infecção pelo Papilomavírus humano e a detecção de anormalidades citológicas em jovens universitárias
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Data
2011-03-18
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Universidade Federal de Goiás
Resumo
Human papillomavirus (HPV) infection is the most common sexually transmitted
infection (STI) in several countries, being more prevalent in women younger than
25 years of age. The prevalence of HPV genotypes in women with and without
cervical abnormalities may vary according to the population or region studied. HPV
16 is the most commonly type, both in women with cytological abnormalities and
women with normal cytological outcomes. The objective of this study was to
evaluate the association between HPV infection and the detection of cytological
abnormalities in young female university students. Two hundred female university
students aged 17 – 25 years from Goiânia and other cities were included. Cervical
specimens were screened for cytological abnormalities by conventional cytology
and tested for 37 HPV genotypes by PGMY09/11 PCR, followed by reverse
hybridization in a strip with type-specific probes. HPV infection was detected in
47% (94/200) of cases. Infections with high-risk HPV types were more prevalent
(77.7%; 73/94) than low-risk HPV types (22.3%; 21/94). HPV prevalence was
70.6% (12/17) among students with abnormal cytology and 45.1% (80/179) in
students whit normal cervical cytology. Both in cases of normal and abnormal
cytology, HPV 16 was the most common type. Analysis showed there was
statistical significantly association between infection with any HPV type and the
detection of cytological abnormalities (OR = 3.0; 95% CI 1.0–8.8). Therefore, there
was no significantly association between positivity for high-risk HPV types and an
abnormal cytological result (OR = 2.1; 95% IC 0.8–5.8). These data suggest that,
in the population study, the risk of cervical abnormalities is higher in HPV positive
cases.
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OLIVEIRA, Daniel Fernandes de. Associação entre a infecção pelo Papilomavírus humano e a detecção de anormalidades citológicas em jovens universitárias. 2011. 89 f. Dissertação (Mestrado em Medicina Tropical e Saúde Publica) - Universidade Federal de Goiás, Goiânia, 2011.