Envolvimento de células ER-MP58+ na produção de IL-12 em linfonodos drenantes da infecção inicial por leishmania major em camundongos BALB/c
| dc.contributor.advisor-co1 | Lima, Glória Maria Collet de Araújo | |
| dc.contributor.advisor-co1Lattes | http://lattes.cnpq.br/9228137287854181 | por |
| dc.contributor.advisor1 | Oliveira, Milton Adriano Pelli de | |
| dc.contributor.advisor1Lattes | http://lattes.cnpq.br/2152513705182408</dcvalue | por |
| dc.creator | Cardoso, Ludimila Paula Vaz | |
| dc.creator.Lattes | http://lattes.cnpq.br/5434857923089593</dcvalue | por |
| dc.date.accessioned | 2014-08-05T11:56:01Z | |
| dc.date.issued | 2006 | |
| dc.description.abstract | The development of a Th1 immune response is the key event to prevent Leishmania infection and is linked with the IL-12 production by monocytes, dendritic cells, macrophages and neutrophils. The IL-12 signal induces the increase of IFN-γ production by T cells, favoring the profile of the Th1 immune response and the resistance phenotype to the infection. In the vertebrate host, the leishmania inhabits in cells of the mononuclear phagocyte system (MPS), which is also responsible for the elimination of the parasite. The participation of immature cells of MPS in the initial production of IL-12 has been discussed. It was demonstrated recently that a population of mononuclear phagocytes, derived from bone marrow culture and expressing the marker ER-HR3 produced great amount of IL-12p40 after stimulation in vitro with procyclic or metacyclic promastigotes of L. (L.) major. The initial production of IL-12 by MPS cells is under investigation. It is unclear the role of mononuclear phagocytes, in different stages of maturation, in the production of IL-12p40 in vivo. In this work, we evaluated the involvement of MPS cells, in different stage of maturation, with the IL-12p40 production in vivo in draining lymph nodes of BALB/c mice after 48 h of infection with L. (L.) major. Our results showed that CD31+ cells (mononuclear phagocytes precursors) were absent in the draining lymph nodes of the subcutaneously footpad injection and that the number of ER-MP58+ (immature mononuclear phagocytes), ER-HR3+ cells (mononuclear phagocytes in the intermediate stage of maturation) and 33D1+ (mature phagocytes) increase in the period of 48 h after infection. We showed, also, that ER-MP58+ responsible for great part of the draining lymph nodes IL-12 production 48 h after infection with stationary-phase promastigotes of L. (L.) major in mice BALB/c. We suggested that, in vivo, the ER-MP58+ population, together with other cellular populations, known as IL-12 producers, ER-MP58+ cell has an important role in the inflammation induced by the parasitic inoculum. | eng |
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| dc.description.resumo | O desenvolvimento de uma resposta imune do tipo Th1 é o evento chave para prevenir a infecção murina por Leishmania e está interligada à produção de IL-12 por monócitos, células dendríticas, macrófagos e neutrófilos. A sinalização via IL-12 aumenta a produção de IFN-γ por células T, favorecendo o perfil Th1 da resposta imune e o fenótipo de resistência à infecção. A leishmania, no hospedeiro vertebrado, reside em células do sistema fagocítico mononuclear (SFM), o qual também é responsável pela eliminação do parasito. A participação de células indiferenciadas do SFM na produção de IL-12 vem sendo discutida. Foi demonstrado recentemente que uma população de fagócitos mononucleares, derivados de cultura de medula óssea e expressando o marcador ER-HR3 produzia grande quantidade de IL-12p40 após estimulação in vitro com formas procíclicas ou metacíclicas de L. (L.) major. A produção de IL-12 na infecção por L. (L.) major por fagócitos em diferentes estágios de maturação in vivo ainda não está claro. Neste trabalho, avaliamos o envolvimento de células em diferentes estágios de maturação em linfonodos drenantes após 48 h de infecção por L. (L.) major em camundongos BALB/c, quanto à produção de IL- 12p40. Verificamos que células CD31+ (precursores de fagócitos mononucleares) estão ausentes nos linfonodos drenantes do sítio do inóculo e que o número de células ER-HR3+ (fagócitos mononucleares em estágio intermediário de maturação), células ER-MP58+ (fagócitos imaturos) e 33D1+ (subpopulações de células dendríticas) aumenta no período de 48 h após a infecção. Mostramos também que, células ER-MP58+ são as principais responsáveis por grande parte da produção de IL-12 nos linfonodos drenantes 48 h após a infecção por L. (L.) major em camundongos BALB/c. Sugerimos que, in vivo, a população ER-MP58+ com as outras populações celulares, conhecidas como produtoras de IL-12, têm um papel relevante na inflamação induzida pelo inóculo parasitário. | por |
| dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES | por |
| dc.format | application/pdf | * |
| dc.identifier.citation | CARDOSO, Ludimila Paula Vaz. Envolvimento de células ER-MP58+ na produção de IL-12 em linfonodos drenantes da infecção inicial por Leishmania major em camundongos BALB/c. 2006. 77 f. Dissertação (Mestrado em Medicina) - Universidade Federal de Goiás, Goiânia, 2006. | por |
| dc.identifier.uri | http://repositorio.bc.ufg.br/tede/handle/tde/2879 | |
| dc.language | por | por |
| dc.publisher | Universidade Federal de Goiás | por |
| dc.publisher.country | Brasil | por |
| dc.publisher.department | Faculdade de Medicina - FM (RG) | por |
| dc.publisher.initials | UFG | por |
| dc.publisher.program | Programa de Pós-graduação em Medicina Tropical e Saúde Publica (IPTSP) | por |
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Immunol. 172 (7):4410-7. Sypek JP, Chung CL, Mayor SE, Subramanyam JM, Goldman SJ, Sieburth DS, Wolf SF,Schaub RG 1993. Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response. J. Exp. Med. 177 (6). 1797-802. Taswell C 1986. Cell separation: selected methods and applications. In Pretlow TG, Pretlow TP (Eds.) Limiting dilution assays for the separation, characterization and quantification of biologically active particles and their clonal progeny: statistical methods for LDAs used by ELIDA. Academic Press, New York, 109-145. Trinchieri G & Gerosa F 1996. Immunoregulation by interleukin-12. Journal of Leukocyte Biology. 59 (4):505-11. Trinchieri G 1998. Interleukin-12: a cytokine at the interface of inflamation and immunity. Adv. Immunol. 70: 83-243. Turpin JA, Lopez-Berestein G 1992. Differentiation, maturation, and activation of monocytes and macrophages: functional a activity is controlled by a continuum of maturation. In: G. Lopez-Berestein e K. J. (Ed.). Mononuclear Phagocytes in Cell Biology. Boca Raton: CRC Press 71-99. von Stebut E, Belkaid Y, Jakob T, Sacks DL, Udey MC 1998. Uptake of Leishmania major amastigotes results in activation and interleukin 12 release from murine skin- derived dendritic cells: implications for the initiation of anti-Leishmania immunity. J Exp Med. 19; 188 (8):1547-52. WHO 1998. Information by topic or disease: leishmaniasis. http://www.who.int/tdr/diseases/leish/default.htm. Williams RO 1988. Invasion of murine dendritic cells by Leishmania major and Leishmania mexicana mexicana. J Parasitol. 74(1):186-7. | por |
| dc.rights | Acesso aberto | por |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject | Leishmania major | por |
| dc.subject | Interleucina 12 | por |
| dc.subject | Células ER-MP58+ | por |
| dc.subject | Linfocinas | por |
| dc.subject | Células ER-HR3+ | por |
| dc.subject | Resposta imune | por |
| dc.subject.cnpq | CIENCIAS DA SAUDE::MEDICINA | por |
| dc.thumbnail.url | http://repositorio.bc.ufg.br/tede/retrieve/5991/ludimilacardoso.pdf.jpg | * |
| dc.title | Envolvimento de células ER-MP58+ na produção de IL-12 em linfonodos drenantes da infecção inicial por leishmania major em camundongos BALB/c | por |
| dc.type | Dissertação | por |
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