Efeito de um extrato de ervas sobre a ingestão alimentar e concentrações de grelina acilada e peptídeo semelhante ao glucagon 1 em mulheres com excesso de peso
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2016-02-05
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Universidade Federal de Goiás
Resumo
Overweight and obesity are associated with excessive food intake,
due to changes in the productions of gastrointestinal hormones productions.
Objectives: To evaluated the effect of a herbal extract derived from native species of
South America on food intake, acylated ghrelin concentrations and peptide similar to
glucagon 1. Material and methods: A randomized, blind, placebo-controlled,
crossover design methodology, with intervention in two days with an interval
(washout) seven days, consisted of 20 overweight women. Three capsules a mix of
herbal medicines were administered, containing 112 mg of yerba mate, guarana 95
mg and 36 mg of damiana, or three placebo capsules containing 100 mg of lactose.
The herbal extract was administered 15 minutes before a standardized breakfast
(494.50 kcal, carbohydrates 52.67%, 12.91% protein and 34.5% lipid) and a standard
lunch (632.05 kcal, 61, 67% carbohydrates, 16.97% protein and 21.44% lipid) for all
patients. Food not eaten by the participants was weighed to evaluated food intake.
Blood samples were collected at baseline and on days 45, 60, 90, 150, 210 minutes
after breakfast in the morning and lunch for determination of plasma glucose
concentrations, acylated ghrelin and peptide similar to glucagon 1. To compare the
differences of the mean energy food intake and macronutrient was performed paired
t-test, for the behavior of hormones was performed ANOVA and was calculated area
under the curve and to determine the differences between the areas was performed
Student's t test. Results: In the supplemented group, there was significant reduction
in energy intake at lunch and macronutrients in both meals (p <0.05). The acylated
ghrelin concentrations were lower after breakfast (p <0.05) and glucagon-like peptide
1 were higher (p <0.05) after breakfast in the supplemented group. Conclusion:
Supplementation with herbal mix reduced energy intake and macronutrients by the
modulating hormones glucagon-like 1 and acylated ghrelin in overweight and obesity
women.
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CELESTINO, M. M. Efeito de um extrato de ervas sobre a ingestão alimentar e concentrações de grelina acilada e peptídeo semelhante ao glucagon 1 em mulheres com excesso de peso. 2016. 133 f. Dissertação (Mestrado em Nutrição e Saúde) - Universidade Federal de Goiás, Goiânia, 2016.