SISTEMA DE BARREIRA COM FILME DE HIDROGEL DE POLI(2-HIDROXIETIL METACRILATO) NA PREVENÇÃO DE ADERÊNCIAS PERITONIAIS : ESTUDO EXPERIMENTAL EM RATAS E CADELAS
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Data
2009-01-16
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Universidade Federal de Goiás
Resumo
Synthetic materials are the leading choice for the correction of defects in
abdominal wall, but the formation of adhesions are a problem encountered
when placing implants in contact with the abdominal viscera. With
In order to avoid its formation, various materials and mechanisms are used
in an attempt to prevent contact with peritoneal surfaces of the prostheses.
In this sense, we investigated the possibility of the hydrogel poly (2-hydroxyethyl
methacrylate) (polyHEMA) coating a face of polypropylene mesh and thereby
preventing peritoneal adhesion in dogs and rats, and, in the latter species,
also performed a histological evaluation of implanted materials. For this,
an abdominal defect was created in the rectus abdominis of 16 bitches
were divided into two groups of eight animals and the defect was corrected with screen
polypropylene and polypropylene mesh coated with hydrogel, respectively. The
presence of adhesions was evaluated after 20 days by laparoscopy. As
to rats, the surgical procedure was similar and the evaluations were performed at
15 and 30 days, with euthanasia and collection of fragments for histology
with picrosirius red staining and HE The hydrogel coating the polyHEMA
polypropylene mesh implanted in the abdominal wall prevented completely
visceral adhesions and omentum remaining on the surface
the screen when compared to polypropylene mesh in dogs and isolated rats. Was
found greater amount of adhesions in the suture zone in the group
a mesh coated with polyHEMA. The physical structure of the biomaterial interfered
the organization and persistence of tissue response, but not in the same type.
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Citação
SILVA, Marcelo Seixo de Brito e. SYSTEM WITH BARRIER FILM hydrogel poly (2-hydroxyethyl
METHACRYLATE) IN PREVENTION OF peritoneal adhesions:
EXPERIMENTAL STUDY IN RATS AND bitches. 2009. 61 f. Tese (Doutorado em Ciências Agrárias) - Universidade Federal de Goiás, Goiânia, 2009.