Estudo comparativo entre a angiografia por OCT e a angiografia aom fluoresceína sódica sa maculopatia isquêmica diabética
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2016-12-13
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Universidade Federal de Goiás
Resumo
The purpose of this study is to compare fluorescein angiography and optical coherence tomography
(OCT) angiography images of foveal avascular zone (FAZ) in patients with diabetic retinopathy
(DR) with and without diabetic macular ischemia. Regarding our methods, the Wilcoxon signedrank
test was used to compare area measurements and P values of < 0.05 were considered
statistically significant. Fluorescein angiography and OCT angiography images were independently
graded by 2 observers that reached agreement regarding quantitative diabetic macular ischemia
according established protocols. The ischemic area was divided into “moderate” and ‘‘large’’
macular ischemia (with diabetic macular ischemia) and ‘‘small’’ (without diabetic macular
ischemia) groups. Quantitative analyses of the FAZ were performed using custom software
(ImageJ64; National Institute of Health - NIH; http://rsbweb.nih.gov/ij/; public domain).
Considering our results, thirty-four eyes from 34 diabetic patients were enrolled. Subjects with
diabetic macular ischemia presented a mean area on fluorescein angiography and OCT
angiography of 0.68 + 0.53 mm2 and 0.58 + 0.35 mm2, respectively (p = 0.1374). Patients without
diabetic macular ischemia presented a mean area on fluorescein angiography and OCT
angiography of 0.19 + 0.67 mm2 and 0.20 + 0.79 mm2, respectively (p = 0.9594). The ICC for the
FAZ measurements between the 2 observers on fluorescein angiography and OCT angiography
was 0.96 and 0.92, respectively. Thereby, OCT angiography may represent a novel technique for
the diagnosis of diabetic macular ischemia and could become an alternative to FA for this purpose.
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GARCIA, J. M. B. B. Estudo comparativo entre a angiografia por OCT e a angiografia aom fluoresceína sódica sa maculopatia isquêmica diabética. 2016. 62 f. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal de Goiás, Goiânia, 2016.