Lactato sérico em recém-nascidos asfíxicos: uma coorte histórica

Abstract

Background: Perinatal asphyxia (AP) is the leading cause of death in the neonatal period and there is no consensus in the literature on its adequate diagnosis. Serum lactate is a promising laboratory marker and has been scarcely studied in the literature. Objective: To correlate serum lactate level with the diagnosis of perinatal asphyxia. Methods: This is a descriptive study of a historical cohort performed through the analysis of medical records of newborns with gestational age greater than or equal to 34 weeks, who had lactate levels in the first 24 hours of life and were admitted to the neonatal intensive care unit of the Clinics of the Federal University of Goiás from 2015 to 2018. We analyzed the serum lactate level with one hour of life and 24 hours of life. Statistical analysis was performed using SPSS v.20 software (SPSS Inc .; Chicago, IL). Results: The final sample consisted of 92 children, with a mean gestational age of 36.5 weeks, weight average of 2,746.7 grams, 52.2% male and 47.8% female. In children diagnosed with perinatal asphyxia, the serum lactate value in the first hour of life was significantly higher (p = 0.003) compared to the non-asphyxiated group. At 24 hours of life there was a relative decrease in lactate value, but still remained higher in newborns with perinatal asphyxia. Conclusions: There was a strong correlation between increased serum lactate in the first hours of life and the diagnosis of perinatal asphyxia.