Vaccination and immunological profile for COVID-19: a cohort among pregnant women treated at two Basic Health Units in the state of Goiás, between 2021 and 2022

Abstract

Objective: this study aimed to analyze the vaccination and immunological profile for COVID-19 in pregnant women treated at Basic Health Units in Goiânia, GO, Brazil, between May 2021 and July 2022. Methods: this is a prospective cohort study. The participants were selected by convenience, signed a consent form, answered a questionnaire, and had blood samples collected for anti-SARSCoV-2 (immunochromatography). This procedure was repeated up to three times throughout the pregnancy. After delivery, new samples were collected from the postpartum woman and the newborn for analysis. Results: the seroprevalence for IgG anti-SARS-CoV-2 among the 66 pregnant women monitored was 83.3%. It was ascertained that two or three doses of a COVID-19 vaccine produce a more effective immune response than just one dose. More than 75% of newborns presented SARSCoV-2 IgG antibodies. Conclusion: these data are relevant to encourage vaccination of pregnant women, following the complete vaccination schedule, and breastfeeding.