A FF - Faculdade de Farmácia, da Universidade Federal de Goiás, oferece curso de Graduação em: Farmácia. Além de Especialização em: Fitoterapia; e, Citologia Clínica.
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Navegando FF - Faculdade de Farmácia por Assunto "Absorção de ferro"
(2005-03) Conceição, Edemilson Cardoso da; Machado, Alexandre Alves; Izumi, Clarice; Freitas, Osvaldo de
Experimental and epidemiological
evidences have demonstrated that calcium inhibits iron
absorption; calcium carbonate being one of the most
effective calcium sources to reduce iron absorption from
dietary origin or from iron sulfate. In the present work,
the short-term effect of calcium from calcium carbonate
on iron absorption was studied in rats, using different
iron compounds (monosodium ferric EDTA, iron-bysglicine,
iron peptide complex) with iron sulfate as a
control. Eighty (80) animals were divided into groups
of 10 animals each with homogeneous weight. After 18h
fast, the animals received by gavage 5 mL of a dispersion
containing one of the iron compounds (1mg Fe/kg body
weight), concomitantly or not with calcium carbonate
at a molar ratio of 150:1 (Ca/Fe). Two hours after the
administration, the animals were sacrificed and blood
was collected for serum iron determination (iron transfer
rate from intestinal lumen to blood compartment).
Additionally, the intestines were collected for soluble
iron determination (available iron). The results
demonstrated that calcium ion from calcium carbonate
inhibits the iron absorption from iron sulfate, but not
from organic iron (di- or trivalent) complexes.