FEN - Faculdade de Enfermagem
URI Permanente desta comunidade
A FEN - Faculdade de Enfermagem, da Universidade Federal de Goiás, oferece curso de Graduação em: Enfermagem. E os cursos de Especialização (Lato Sensu) em: Multiprofissional em Saúde Mental; e, Multiprofissional em Saúde do Trabalhador.
Navegar
Navegando FEN - Faculdade de Enfermagem por Assunto "Abuso de substâncias por via intravenosa"
Agora exibindo 1 - 1 de 1
Resultados por página
Opções de Ordenação
Item Prevalência, fatores de risco e genótipos da hepatite C entre usuários de drogas(2009) Lopes, Carmen Luci Rodrigues; Teles, Sheila Araújo; Santo, Márcia Paschoal do Espírito; Lampe, Elisabete; Rodrigues, Fabiana Perez; Castro, Ana Rita Coimbra Motta; Marinho, Thaís Augusto; Reis, Nádia Rúbia da Silva; Silva, Ágabo Macedo da Costa e; Martins, Regina Maria BringelOBJECTIVE: To estimate prevalence of hepatitis C virus (HCV) infection and identify risk factors associated and circulating HCV genotypes and subtypes. METHODS: Study conducted including 691 drug users attending 26 charitable, private and public drug treatment centers in Goiânia and Campo Grande, centralwestern Brazil, between 2005 and 2006. Sociodemographic characteristics and risk factors for HCV infection were collected during interviews. Blood samples were tested for HCV antibodies (anti-HCV). Positive samples were submitted to HCV RNA detection by PCR with primers complementary to 5’ NC and NS5B regions of viral genome and genotyped by line probe assay (LiPA) and direct nucleotide sequencing followed by phylogenetic analysis. The prevalence and odds ratio were calculated with 95% confi dence intervals. Risk factors were fi rst estimated in the univariate analysis (p<0.10) and then analyzed by hierarchical logistic regression. Statistical signifi cance was assessed at a 5% signifi cance level. RESULTS: The prevalence of anti-HCV was 6.9% (95% CI: 5.2–9.2). The multivariate analysis of risk factors revealed that age over 30 years and injecting drug use were associated with HCV infection. HCV RNA was detected in 85.4% (41/48) of anti-HCV-positive samples. Thirty-three samples were genotyped as genotype 1 by LiPA, subtypes 1a (63.4%) and 1b (17.1%), and 8 samples (19.5%) were genotype 3, subtype 3a. The phylogenetic analysis of the NS5B region showed that 17 (68%), 5 (20%), and 3 (12%) samples were subtypes 1a, 3a, and 1b, respectively. CONCLUSIONS: The results show a high prevalence of HCV infection and predominance of subtype 1a among drug users in Brazil. In addition, injecting drug use was a major risk factor associated with HCV infection.