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Item Avaliação de toxicidade aguda: estratégias após a “era do teste DL50“(Marize Campos Valadares, 2006) Valadares, Marize CamposThe present work discuss about the evaluation of the acute systemic toxicity post deletion of the LD50 test (median lethal dose). The three alternative animal tests now employed, the Fixed Dose Procedure, the Acute Toxic Class Method and the Up and Down Procedure, give rise to significant improvements in animal welfare. Although, the total replacement of animal tests it is not possible yet, basal cytotoxicity in vitro has been used as adjunct to these alternative animal tests to select initial doses, thus reducing the numbers of animals used during the evaluation of acute systemic toxicity.