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dc.creatorMartins, Daniella Ramos-
dc.creatorPazini, Francine-
dc.creatorAlves, Vinícius de Medeiros-
dc.creatorMoura, Soraya Santana de-
dc.creatorLiao, Luciano Morais-
dc.creatorMagalhães, Mariana Torquato Quezado de-
dc.creatorValadares, Marize Campos-
dc.creatorAndrade, Carolina Horta-
dc.creatorMenegatti, Ricardo-
dc.creatorRocha, Matheus Lavorenti-
dc.date.accessioned2018-08-27T11:23:32Z-
dc.date.available2018-08-27T11:23:32Z-
dc.date.issued2013-05-
dc.identifier.citationMARTINS, Daniella Ramos et al. Synthesis, docking studies, pharmacological activity and toxicity of a novel pyrazole derivative (LQFM 021)-possible effects on phosphodiesterase. Chemical and Pharmaceutical Bulletin, Tokyo, v. 61, n. 5, p. 524-531, May 2013.pt_BR
dc.identifier.issn0009-2363-
dc.identifier.issne- 1347-5223-
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/15741-
dc.description.abstractThis study describes the synthetic route and molecular computational docking of LQFM 021, as well as examines its biological effects and toxicity. The docking studies revealed strong interaction of LQFM 021 to phosphodiesterase-3 (PDE-3). In isolated arteries, the presence of endothelium potentiates the relaxation for LQFM 021 and the inhibition cyclic nucleotides reduced the relaxation. Pre-contraction with KCl (45 mm), the treatment with tetraethylammonium (TEA) (5 mm) and inhibition of reticular Ca2+-ATPase showed an inhibitory effect on relaxation. Moreover, the compound reduced the contraction evoked by the Ca2+ influx. Acute toxicity tests revealed that the compound was practically nontoxic. In conclusion, this study showed that a new synthetic derivative of pyrazole is a possible PDE-3 inhibitor and has vasorelaxant activity and low toxicitypt_BR
dc.language.isoengpt_BR
dc.rightsAcesso Abertopt_BR
dc.rights.uriAn error occurred getting the license - uri.*
dc.subjectPyrazolept_BR
dc.subjectPhosphodiesterasept_BR
dc.subjectRelaxationpt_BR
dc.subjectAortapt_BR
dc.subjectCyclic nucleotidept_BR
dc.titleSynthesis, docking studies, pharmacological activity and toxicity of a novel pyrazole derivative (LQFM 021) - possible effects on phosphodiesterasept_BR
dc.typeArtigopt_BR
dc.publisher.countryBrasilpt_BR
dc.identifier.doi10.1248/cpb.c12-01016-
dc.publisher.departmentInstituto de Química - IQ (RG)pt_BR
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