Long-term effects of nifedipine on human gingival epithelium: a histopathological and immunohistochemical study
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Data
2010
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Resumo
The chronic usage of nifedipine is
associated with the appearance of gingival overgrowth
(GO). The frequency of GO associated with chronic
nifedipine therapy remains controversial and the
possible subclinical effects of this drug on the gingival
epithelium should be investigated. We investigated the
epithelial proliferation index and apoptosis rate, and
their association with epithelial enlargement.
Proliferation (Ki67 and Cyclin B1) and apoptosis
(BCL2, Bax and p53) markers were identified by
immunohistochemistry in twenty-one samples of
gingival tissue from patients undergoing chronic
treatment with nifedipine and in eleven samples of
gingival tissue from healthy patients who did not use
drugs associated with GO (control). Our results show
that the epithelial tissue of nifedipine users has
considerably longer rete pegs compared to control (P
= 0.01). However, the density of Ki67 + and Cyclin B1 +
cells was similar in both groups. Regarding apoptosis,
we found more BCL2 + cells in the nifedipine group when
compared to controls (P = 0.12). An increase in Bax +
cells in the nifedipine group compared to control (P =0.003) was also seen, and slightly lower levels of p53 +
expression were observed (P = 0.51). Our results suggest
that the chronic use of nifedipine is not associated with
subclinical changes in gingival tissue. (J Oral Sci 52,
55-62, 2010).
Descrição
Palavras-chave
Cell proliferation, Gingival overgrowth, Apoptosis, Adverse effect, Nifedipine
Citação
CASTRO, Luciano A. et al. Long-term effects of nifedipine on human gingival epithelium: a histopathological and immunohistochemical study. Journal of Oral Science, Tokyo, v. 52, n. 1, p. 55-62, 2010.