Rotavirus A infections and reinfections: genotyping and vaccine implications
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2004
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Objective: To identify rotavirus A and the most prevalent G and P genotypes in children with acute
diarrhea, and to the describe the occurrence of rotavirus infection and reinfection.
Methods: Group A rotavirus specimens were obtained from fecal samples from children with acute
diarrhea in Goiânia, state of Goiás, Brazil from July 2000 to October 2002. Rotavirus A positive children
and a control group (children of the same age and sex, without diarrhea and with no evidence of rotavirus
in the first fecal samples) were followed prospectively during one year. All rotavirus A positive samples
were genotyped using RT-PCR/nested-PCR.
Results: A total of 77 group A rotavirus strains (37.2%) were identified in the diarrheic samples
of 207 children. The following G genotypes were identified: G1 (62.3%), G9 (34.4%) and G4 (3.3%).
With regard to P genotyping, 59% were characterized as P[8], 7.7% as P[6], 23.1% as P[6]+P[8], 7.7%
as P[4]+P[8] and 2.6% as P[4]+P[8]. The following associations were observed: G1P[8] (77.8%),
G9P[8] (11.1%), G4P[8] (5.6%) and G1P[6] (5.6%). No reinfection was observed in the 40 rotavirus
A (+) children. However, but two of 40 children who were initially negative for this agent developed
rotavirus infection during the same period.
Conclusions: The predominant G and P genotypes observed were similar to those found in new
vaccines. No reinfection occurred during one-year of follow-up for any of the genotypes identified.
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COSTA, Paulo S. S.; CARDOSO, Divina D. P.; GRISI, Sandra J. F. E.; SILVA, Paula A.; FIACCADORI, Fabíola; SOUZA, Menira B. L. D.; SANTOS, Rodrigo A. T. Rotavirus A infections and reinfections: genotyping and vaccine implications. Jornal de Pediatria, Porot Alegre, Rio de Janeiro, v. 80, n. 2, p. 119-122, 2004.