Extrato hidroalcoolico da casca do pequi (Caryocar brasiliense) em ratos submetidos à aplicação de doxorrubicina
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Data
2013-01
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Resumo
The objective of this study was to evaluate the
antioxidant effect of the hydroalcoholic extract of pequi peel
(HEPP) in rats after administration of doxorubicin (DOX).
Were used 26 Wistar rats divided into four groups, which G1
(n=6) received water and saline solution (control group), G2
(n=7) HEPP and saline solution, G3 (n=7) water and DOX,
and G4 (n=6) HEPP and DOX. The HEPP was administered
by gavage for 10 days to G2 and G4 and water to G1 and G3.
DOX and saline solution were administered intravenously on
day seven after the start of the experiment, with the DOX (10mg
kg-1) applied in G3 and G4, and saline solution 0.9% in G1
and G2. Were evaluated weight and mortality rate. Ten days
after the start of the experiment were evaluated creatina kinase
MB (CK-MB), troponin and myoglobin, and the rats were
euthanized and evaluated morphologically. There was no
difference between treatments in weight of animals (P>0.05).
About the mortality rate an increase in group 2 was showed
(P<0.05). The results of the qualitative test for the detection of
CK-MB, troponin I and myoglobin in the four groups were
negative and there were no macroscopic changes in different
rat’s organs of different groups. Multifocal and moderate to
severe acute tubular necrosis in cortical and medullary regions
of the kidneys was observed in all rats studied. DOX intravenous
and in a one dose of 10mg kg-1 don’t induce cardiac changes
in rats and the HEPP in conditions here evaluated increase the
rate of mortality of rats, which may be related to toxic substances
in the peel of this fruit.
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Estresse oxidativo, Cardiotoxicidade, Antracilcinas, Antioxidante, Fruto do cerrado, Oxidative stress, Cardiotoxicity, Anthracyclines, Antioxidant,, Cerrado fruit
Citação
MOURA, Léa Resende; MARTINS, Aparecida Conceição; VAZ, Liliam Aparecida da Rocha; ORPINELLI, Stiwens Roberto Trevisan; SILVA, Thiago Lopes; FALEIRO, Mariana Batista Rodrigues; SANTOS, Suzana da Costa; MOURA, Veridiana Maria Brianezi Dignani de. Extrato hidroalcoolico da casca do pequi (Caryocar brasiliense) em ratos submetidos à aplicação de doxorrubicina. Ciência Rural, Santa Maria, v. 43, n. 1, p. 100-106, 2013.