Synthesis, docking studies, pharmacological activity and toxicity of a novel pyrazole derivative (LQFM 021) - possible effects on phosphodiesterase
Data
2013-05
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Resumo
This study describes the synthetic route and molecular computational docking of LQFM 021, as well as
examines its biological effects and toxicity. The docking studies revealed strong interaction of LQFM 021 to
phosphodiesterase-3 (PDE-3). In isolated arteries, the presence of endothelium potentiates the relaxation for
LQFM 021 and the inhibition cyclic nucleotides reduced the relaxation. Pre-contraction with KCl (45 mm),
the treatment with tetraethylammonium (TEA) (5 mm) and inhibition of reticular Ca2+-ATPase showed an
inhibitory effect on relaxation. Moreover, the compound reduced the contraction evoked by the Ca2+ influx.
Acute toxicity tests revealed that the compound was practically nontoxic. In conclusion, this study showed
that a new synthetic derivative of pyrazole is a possible PDE-3 inhibitor and has vasorelaxant activity and
low toxicity
Descrição
Palavras-chave
Pyrazole, Phosphodiesterase, Relaxation, Aorta, Cyclic nucleotide
Citação
MARTINS, Daniella Ramos et al. Synthesis, docking studies, pharmacological activity and toxicity of a novel pyrazole derivative (LQFM 021)-possible effects on phosphodiesterase. Chemical and Pharmaceutical Bulletin, Tokyo, v. 61, n. 5, p. 524-531, May 2013.