Repeated amygdala-kindled seizures induce ictal rebound tachycardia in rats
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Data
2011
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Resumo
It is thought that cardiovascular changes may contribute to sudden death in patients with epilepsy. To
examine cardiovascular alterations that occur during epileptogenesis, we measured the heart rate of rats
submitted to the electrical amygdala kindling model. Heart rate was recorded before, during, and after the
induced seizures. Resting heart rate was increased in stages 1, 3, and 5 as compared with the unstimulated
control condition. In the initial one third of the seizures, we observed bradycardia, which increased in
intensity with increasing stage and was blocked by injecting methyl atropine. During stage 5 seizures, a
rebound tachycardia was observed that also increased in intensity with increasing number of seizures. This
study demonstrated the influence of seizure frequency on cardiac autonomic modulation, providing a basis for
discussion of potential mechanisms that cause patients with epilepsy to die suddenly.
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Sudden unexpected death in epilepsy, Heart rate, Kindling, Seizure frequency
Citação
PANSINI, Aline P. et al. Repeated amygdala-kindled seizures induce ictal rebound tachycardia in rats. Epilepsy & Behavior, Amsterdã , v. 22, p. 442-449, 2011.