Cerumenogram: a new frontier in cancer diagnosis in humans
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2019-08
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Cancer is the deadliest human disease and the development of new diagnosis methods is important to
increase the chances of a cure. In this work it was developed a new method, named here for the frst
time as cerumenogram, using cerumen (earwax) as a new biomatrix for diagnosis. Earwax samples
collected from cancer patients (cancer group) and cancer-free patients (control group) were analyzed
by Headspace/Gas Chromatography-Mass Spectrometry (HS/GC-MS), following with multivariate
analysis steps to process the raw data generated. In total, 158 volatile organic metabolites (VOMs) were
identifed in the cerumen samples. The 27 selected as potential VOMs biomarkers for cancer provided
100% discrimination between the cancer and control groups. This new test can thus be routinely
employed for cancer diagnoses that is non-invasive, fast, cheap, and highly accurate.
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BARBOSA, João Marcos Gonçalves Barbosa et al. Cerumenogram: a new frontier in cancer diagnosis in humans. Scientific Reports, London, v. 9, n. 1, e11722, 2019. DOI: 10.1038/s41598-019-48121-4. Disponível em: https://www.nature.com/articles/s41598-019-48121-4. Acesso em: 14 jun. 2023.