Nutritional and metabolic risk factors for insulin resistance in adults
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Data
2011-08
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Resumo
The purpose of this study is to investigate the association of insulin resistance (IR) with dietary, fitness,
anthropometric and other components of Metabolic Syndrome (MS) in adult participants. Cross-
sectional study of 80 adult participants (58±8 years old) were clinically and ethically selected. They were
all assessed for anthropometry, dietary habits, plasma biochemistry and indirect measurement of
maximal oxygen uptake (VO 2 max). Participants were diagnosed for MS by IDF criterion and placed in 3
different groups using tertiles of HOMA-IR. Values were statistically correlated with the remaining
variables. Predictors of IR were determined by multivariate regression analysis. HOMA-IR was
significant (p<0.001) and positively associated with MS prevalence (r=0.67), C-reactive protein (r=0.58),
waist circumference (WC) (r=0.55), servings of fat consumption (r=0.52), body weight (r=0.43), body
mass index (r=0.40), uric acid (r=0.40), inversely correlated associated with HDL-c (r=-0.56), VO 2 max (r=-
0.28), ingested fibers (r=-0.47) and fruits (r=-0.39). The fiber intake discriminated tertiles of HOMA-IR
(G1<G2<G3). The variables considered independent predictors of HOMA-IR were WC, fat intake, MS, low
fiber intake, low muscle mass and high plasmatic concentrations of uric acid. The highest values of
HOMA-IR (P75) were positively associated with consumption of refined grains, uric acid, triglycerides,
low consumption of fruit and low HDL-c. Main determinants of IR are preventable factors.
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Palavras-chave
Insulin resistance, Physical fitness, Oxidative stress, Eating habits, Inflammation, Lipoproteins
Citação
MOTA, João Felipe et al. Nutritional and metabolic risk factors for insulin resistance in adults. International Journal of Nutrition and Metabolism, Gillingham, v. 3, n. 7, p. 90-96, Aug. 2011.