Health care workers humoral immune response against GLcB, MPT51 and HSPX from Mycobacterium tuberculosis
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Data
2009-12
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Resumo
Tuberculosis (TB) is one of the oldest human infectious diseases and one third of the world’s population is latently
infected. Brazil is an endemic area for TB. One of the most important challenges in TB control is the identification
of latently infected individuals. Health Care Workers (HCW) are at high risk of being infected with Mycobacterium
tuberculosis and even to become TB latently infected. The aim of this study was to increase knowledge about
humoral immune response in TB latently infected individuals. HCW were classified according to their tuberculin
skin test (TST), as positive or negative. The antibody response to GLcB, MPT51 and HSPX from Mycobacterium
tuberculosis was evaluated. TST negative HCW constituted the majority of those who showed a humoral immune
response. Antibody levels varied according to antigen characteristics, TST and BCG status. We suggest that possibly
the presence of those antibodies could have a function in the protective immune response against Mycobacterium
tuberculosis.
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Latent tuberculosis, Antibodies, Infection
Citação
REIS, Michelle Cristina Guerreiro dos et al. Health care workers humoral immune response against GLcB, MPT51 and HSPX from Mycobacterium tuberculosis. Brazilian Journal of Infectious Diseases, Salvador, v. 13, n. 6, p. 417-421, Dec. 2009.