Altered β-catenin expression in oral mucosal dysplasia: a comparative study
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Data
2015
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Resumo
Obective:
Thee current study aimed to investigate the B-catenin expression in oral
leukoplakia (OL) with different degrees of epithelial dysplasia and normal oral mucosa.
aterial and ethods: ormalin
ed paraf n em edded tissue samples of
OL (mild
dysplasia n=19, moderate dysplasia n=13, and severe dysplasia n=7), and 10 normal oral
mucosa (control group) were su mitted to immunohistochemical reactions to anti catenin
primary anti ody.
ualitative catenin analysis was performed ased on the percentage
of positive cells. The cellular location and the epithelial layer were also considered. The
Chi-square test and the Fisher’s exact test were used to verify possible differences in the
-catenin expression among the OL groups. p-value of 0.0 was considered statistically
signi cant. esults: embranous expression of -catenin in parabasal and basal layers
was gradually lost in the higher degrees of epithelial dysplasia. In normal oral mucosa,
-catenin was detected only in the cytoplasmic membrane. owever, a signi cant increase
in cytoplasmic -catenin could be observed between mild and moderate dysplasia (Fisher
Exact test - p<0.001) and between mild and severe dysplasia (p<0.001). Conclusions: The
-catenin cytoplasmic expression observed in this study may represent the initial stage of
modi cations in the E-cadherin-catenin complex, along with morphological cellular changes.
Descrição
Palavras-chave
Beta-catenin, Oral leukoplakia, Oral dysplasia, Oral cancer
Citação
SILVA, Brunno Santos de Freitas et al. Altered β-catenin expression in oral mucosal dysplasia: a comparative study. Journal of Applied Oral Science, Bauru, v. 23, n. 5, p. 472-478, 2015.