Antinociceptive, anti-inflammatory and anxiolytic-like effects of the ethanolic extract, fractions and Hibalactone isolated from Hydrocotyle umbellata L. (Acariçoba) – Araliaceae
dc.creator | Oliveira, Thiago Levi Silva | |
dc.creator | Morais, Sandra Ribeiro de | |
dc.creator | Sá, Stone de | |
dc.creator | Oliveira, Matheus Gabriel de | |
dc.creator | Florentino, Iziara Ferreira | |
dc.creator | Silva, Dayane Moreira da | |
dc.creator | Carvalho, Verônica Vale | |
dc.creator | Silva, Vinicius Barreto da | |
dc.creator | Vaz, Boniek Gontijo | |
dc.creator | Sabino, José Ricardo | |
dc.creator | Costa, Elson Alves | |
dc.creator | Paula, José Realino de | |
dc.date.accessioned | 2023-05-02T12:14:38Z | |
dc.date.available | 2023-05-02T12:14:38Z | |
dc.date.issued | 2017 | |
dc.description.abstract | Hydrocotyle umbellata Linn. (Araliaceae) is specie used in the treatment of inflammatory diseases. Crude extract (E-HU) was prepared from H. umbellata subterraneous parts and fractionated by liquid-liquid partition, resulting hexane fraction (HF-HU), dichloromethane fraction (DF-HU), ethyl acetate fraction (EAF-HU) and aqueous fraction (AF-HU). The hibalactone (HU-1) was isolated from the DF-HU and its structure was elucidated by 1H NMR and 13C NMR Spectroscopy, mass spectrometry and crystallographic x-ray analysis. The formalin-induced nociception was used to evaluate antinociceptive activity; carrageenan-induced edema and pleurisy tests to evaluate anti-inflammatory activity and light-dark box to evaluate anxiolytic-like activity in mice. The acute oral treatments with E-HU (1000 mg/kg), DF-HU (150 mg/kg), EAF-HU (400 mg/kg) and HU-1 (33 mg/kg) decreased the licking time in both phases of the formalin test. In the carrageenan-induced inflammation models, the treatment with the same doses of E-HU, DF-HU, EAF-HU and HU-1 reduced the paw edema formation and leukocytes account into pleural cavity. In silico findings suggest that hibalactone present anti-inflammatory activity by interacting with the enzymes 5-lipoxygenase and cyclooxygenase-2. In the light dark box, the treatments with DF-HU, EAF-HU and HU-1 revealed an anxiolytic like effect. Thus, the E-HU and fractions of H. umbellata showed antinociceptive, anti-inflammatory and anxiolytic like activities, as also hibalactone, a possible phytoconstituent responsible for the biological effects of this specie. | pt_BR |
dc.identifier.citation | OLIVEIRA,Thiago Levi Silva et al. Antinociceptive, anti-inflammatory and anxiolytic-like effects of the ethanolic extract, fractions and Hibalactone isolated from Hydrocotyle umbellata L. (Acariçoba) - Araliaceae. Biomedicine & Pharmacotherapy, New York, v. 95, p. 837-846, 2017. DOI: 10.1016/j.biopha.2017.08.140. Disponível em: https://www.sciencedirect.com/science/article/pii/S0753332217320139?via%3Dihub. Acesso em: 27 abr. 2023. | pt_BR |
dc.identifier.doi | https://doi.org/10.1016/j.biopha.2017.08.140 | |
dc.identifier.issn | e- 1950-6007 | |
dc.identifier.issn | 0753-3322 | |
dc.identifier.uri | http://repositorio.bc.ufg.br/handle/ri/22431 | |
dc.language.iso | eng | pt_BR |
dc.publisher.country | Estados unidos | pt_BR |
dc.publisher.department | Instituto de Física - IF (RG) | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Hibalactone | pt_BR |
dc.subject | Medicinal plants | pt_BR |
dc.subject | Hydrocotyle umbellata L. | pt_BR |
dc.subject | Anti-inflammatory | pt_BR |
dc.subject | Anxiolytic-like | pt_BR |
dc.subject | Antinociceptive | pt_BR |
dc.title | Antinociceptive, anti-inflammatory and anxiolytic-like effects of the ethanolic extract, fractions and Hibalactone isolated from Hydrocotyle umbellata L. (Acariçoba) – Araliaceae | pt_BR |
dc.type | Artigo | pt_BR |
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