Antinociceptive, anti-inflammatory and anxiolytic-like effects of the ethanolic extract, fractions and Hibalactone isolated from Hydrocotyle umbellata L. (Acariçoba) – Araliaceae

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dc.creatorOliveira, Thiago Levi Silva
dc.creatorMorais, Sandra Ribeiro de
dc.creatorSá, Stone de
dc.creatorOliveira, Matheus Gabriel de
dc.creatorFlorentino, Iziara Ferreira
dc.creatorSilva, Dayane Moreira da
dc.creatorCarvalho, Verônica Vale
dc.creatorSilva, Vinicius Barreto da
dc.creatorVaz, Boniek Gontijo
dc.creatorSabino, José Ricardo
dc.creatorCosta, Elson Alves
dc.creatorPaula, José Realino de
dc.date.accessioned2023-05-02T12:14:38Z
dc.date.available2023-05-02T12:14:38Z
dc.date.issued2017
dc.description.abstractHydrocotyle umbellata Linn. (Araliaceae) is specie used in the treatment of inflammatory diseases. Crude extract (E-HU) was prepared from H. umbellata subterraneous parts and fractionated by liquid-liquid partition, resulting hexane fraction (HF-HU), dichloromethane fraction (DF-HU), ethyl acetate fraction (EAF-HU) and aqueous fraction (AF-HU). The hibalactone (HU-1) was isolated from the DF-HU and its structure was elucidated by 1H NMR and 13C NMR Spectroscopy, mass spectrometry and crystallographic x-ray analysis. The formalin-induced nociception was used to evaluate antinociceptive activity; carrageenan-induced edema and pleurisy tests to evaluate anti-inflammatory activity and light-dark box to evaluate anxiolytic-like activity in mice. The acute oral treatments with E-HU (1000 mg/kg), DF-HU (150 mg/kg), EAF-HU (400 mg/kg) and HU-1 (33 mg/kg) decreased the licking time in both phases of the formalin test. In the carrageenan-induced inflammation models, the treatment with the same doses of E-HU, DF-HU, EAF-HU and HU-1 reduced the paw edema formation and leukocytes account into pleural cavity. In silico findings suggest that hibalactone present anti-inflammatory activity by interacting with the enzymes 5-lipoxygenase and cyclooxygenase-2. In the light dark box, the treatments with DF-HU, EAF-HU and HU-1 revealed an anxiolytic like effect. Thus, the E-HU and fractions of H. umbellata showed antinociceptive, anti-inflammatory and anxiolytic like activities, as also hibalactone, a possible phytoconstituent responsible for the biological effects of this specie.pt_BR
dc.identifier.citationOLIVEIRA,Thiago Levi Silva et al. Antinociceptive, anti-inflammatory and anxiolytic-like effects of the ethanolic extract, fractions and Hibalactone isolated from Hydrocotyle umbellata L. (Acariçoba) - Araliaceae. Biomedicine & Pharmacotherapy, New York, v. 95, p. 837-846, 2017. DOI: 10.1016/j.biopha.2017.08.140. Disponível em: https://www.sciencedirect.com/science/article/pii/S0753332217320139?via%3Dihub. Acesso em: 27 abr. 2023.pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.biopha.2017.08.140
dc.identifier.issne- 1950-6007
dc.identifier.issn0753-3322
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/22431
dc.language.isoengpt_BR
dc.publisher.countryEstados unidospt_BR
dc.publisher.departmentInstituto de Física - IF (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectHibalactonept_BR
dc.subjectMedicinal plantspt_BR
dc.subjectHydrocotyle umbellata L.pt_BR
dc.subjectAnti-inflammatorypt_BR
dc.subjectAnxiolytic-likept_BR
dc.subjectAntinociceptivept_BR
dc.titleAntinociceptive, anti-inflammatory and anxiolytic-like effects of the ethanolic extract, fractions and Hibalactone isolated from Hydrocotyle umbellata L. (Acariçoba) – Araliaceaept_BR
dc.typeArtigopt_BR

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