Serologic screening for Trypanosoma cruzi among blood donors in central Brazil

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dc.creatorAndrade, Ana Lúcia Sampaio Sgambatti de
dc.creatorMartelli, Celina Maria Turchi
dc.creatorOstermayer, Alejandro Luquetti
dc.creatorOliveira, O. S. de
dc.creatorSilva, Simonne Almeida e
dc.creatorZicker, Fabio
dc.date.accessioned2018-04-27T15:26:56Z
dc.date.available2018-04-27T15:26:56Z
dc.date.issued1992
dc.description.abstractThe study reported here compares results obtained by blood banks screening sera for chagasic (Txypanosoma cruzi) infecfion with results obtained by the Chagas’ Disease Reference Laboratory of the Federal University of Goia’s in GoiJnia, Brazil. If also evaluates results obtained using the ELISA technique to screen the study sera. The survey used dafa from six of eight blood banks serving the city of Goirinia, an urban region of Central Brazil where Chagas’ disease is highly endemic. The survey population consisted of 1,513 voluntary firsttime blood donors whose donations occurred between Ocfober 1988 and April 1989. This group included 50% of all the first-time blood donors in that period. The six participating blood banks, which accounted for about 90% of all blood donations in Goilinia during the study period, routinely used indirecf hemagglutination (IHA) and complemenf fixafion (CF) tests to screen sera for antibodies to T. cruzi. Comparison of the resulfs provided by fhe blood banksw ith the referencela boratory’s resulfs indicated a relative sensifivity of 77%, which ranged from 50% to 100% depending on the blood bank studied. The comparison, which found 12 false negative resulfs, indicated that transfusions of infected blood might have occurred despite the serologic screening performed by the blood banks. Relative fo the standard of posifivity established for the study, the enzyme-linked immunosorbenf assay (ELISA) technique was found to have a sensifivify of 96.3%. Considering as pbsitive only those seray ielding positive IHA and indirect immunofluorescence(I IF) test results, the ELISA techniquey ielded 2 false negative and 41 false posifive responsesA. mong the 41 were 34 sera found positive by the ELISA technique alone. These results point to a need for assessing the costs and benefits of introducing the ELISA technique in parallel with blood banks’ serologic fesfing and underscore the desirability of establishing a coherent overall system for moniforing the screening of donated blood for T. cruzi infecfion.pt_BR
dc.identifier.citationANDRADE, A. L. S. Sgambatti de; MARTELLI, C. M. T.; LUQUETTI, A. O.; OLIVEIRA, O. S. de; SILVA, S. Almeida e; ZICKER, F. Serologic screening for Trypanosoma cruzi among blood donors in central Brazil. Bulletin of the Pan American Health Organization, Washington, v. 26, n. 2, p. 157-164, 1992.pt_BR
dc.identifier.issn0085-4638
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/14722
dc.language.isoengpt_BR
dc.publisher.countryEstados unidospt_BR
dc.publisher.departmentInstituto de Patologia Tropical e Saúde Pública - IPTSP (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.titleSerologic screening for Trypanosoma cruzi among blood donors in central Brazilpt_BR
dc.typeArtigopt_BR

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