Antimutagenicity protection of Ginkgo biloba extract (Egb 761) against mitomycin C and cyclophosphamide in mouse bone marrow
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Data
2009
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Resumo
Ginkgo biloba (Egb 761) extract, the most prescribed
phytomedicine in Europe for the treatment of cerebral insufficiency and
vascular diseases, was tested for its possible protective effects against
mitomycin C (MMC)- and cyclophosphamide (CP)-induced mutagen-
icity using the micronucleus test in mouse bone marrow. The extract
was co-administered to mice at doses of 50, 100 and 200 mg/kg (po)
with 4 mg/kg (ip) MMC or 24 mg/kg (ip) CP. All doses of Egb 761 were
significantly (P < 0.05) effective in reducing the frequency of micronu-
cleated polychromatic erythrocytes, when compared with MMC or CP
alone. Based on these results, we suggest that Egb 761 possesses both
direct and indirect antimutagenic potential.
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Palavras-chave
Ginkgo biloba, Micronucleus test, Egb 761, Cyclophosphamide, Antimutagenicity, Mitomycin C
Citação
VILAR, J. B.; LEITE, K. R.; L., Chen Chen. Antimutagenicity protection of Ginkgo biloba extract (Egb 761) against mitomycin C and cyclophosphamide in mouse bone marrow. Genetics and Molecular Research, Ribeirão Preto, v. 8, n. 1, p. 328-333, 2009.