Antimutagenicity protection of Ginkgo biloba extract (Egb 761) against mitomycin C and cyclophosphamide in mouse bone marrow

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dc.creatorVilar, Juliana Brandstetter
dc.creatorLeite, Kaio Ramo
dc.creatorLee, Chen Chen
dc.date.accessioned2018-10-17T10:52:28Z
dc.date.available2018-10-17T10:52:28Z
dc.date.issued2009
dc.description.abstractGinkgo biloba (Egb 761) extract, the most prescribed phytomedicine in Europe for the treatment of cerebral insufficiency and vascular diseases, was tested for its possible protective effects against mitomycin C (MMC)- and cyclophosphamide (CP)-induced mutagen- icity using the micronucleus test in mouse bone marrow. The extract was co-administered to mice at doses of 50, 100 and 200 mg/kg (po) with 4 mg/kg (ip) MMC or 24 mg/kg (ip) CP. All doses of Egb 761 were significantly (P < 0.05) effective in reducing the frequency of micronu- cleated polychromatic erythrocytes, when compared with MMC or CP alone. Based on these results, we suggest that Egb 761 possesses both direct and indirect antimutagenic potential.pt_BR
dc.identifier.citationVILAR, J. B.; LEITE, K. R.; L., Chen Chen. Antimutagenicity protection of Ginkgo biloba extract (Egb 761) against mitomycin C and cyclophosphamide in mouse bone marrow. Genetics and Molecular Research, Ribeirão Preto, v. 8, n. 1, p. 328-333, 2009.pt_BR
dc.identifier.doi10.4238/vol8-1gmr519
dc.identifier.issne- 1676-5680
dc.identifier.urihttp://repositorio.bc.ufg.br/handle/ri/16198
dc.language.isoengpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentInstituto de Ciências Biológicas - ICB (RG)pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectGinkgo bilobapt_BR
dc.subjectMicronucleus testpt_BR
dc.subjectEgb 761pt_BR
dc.subjectCyclophosphamidept_BR
dc.subjectAntimutagenicitypt_BR
dc.subjectMitomycin Cpt_BR
dc.titleAntimutagenicity protection of Ginkgo biloba extract (Egb 761) against mitomycin C and cyclophosphamide in mouse bone marrowpt_BR
dc.typeArtigopt_BR

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