Redundancy of proteins in the salivary glands of Panstrongylus megistus secures prolonged procurement for blood meals
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Data
2011
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Resumo
Panstrongylus megistus, a vector for the Chagas disease parasite Trypanosoma cruzi, is a
hematophagous bug widely distributed in South America. This ubiquitous triatomine is
known to colonize different wild life habitats. Additionally, P. megistus synanthropy, preying
upon mammals, birds, reptiles, and eventually being predators upon insect's hemolymph
probably increases its ability to survive after prolonged fasting. It was suspected that the
P. megistus mechanisms of adaptation to survival might include a salivary gland complex
tool-box with a diversity of pharmacologically active proteins for obtaining blood meals.
Herein we describe comprehensive proteome and transcriptome of the P. megistus salivary
gland. The proteomic analysis led to the identification of 159 proteins, and the
transcriptome revealed 47 complete cDNAs. A diversity of protein functions associated to
blood feeding was identified. The most prevalent proteins were related to blood clotting,
anti-platelet aggregation and anti-vasoconstriction activities, which correlate with the
insect's ability to obtain meals from different sources. Moreover, a gene of resistance to
insecticides was identified. These features augments the comprehension towards
P. megistus enormous capacity to survive in adverse wild life-changing habitats.
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Hematophagous insect, Hemostasis, Proteomics, Salivary glands, Transcriptomics, Lipocalin
Citação
Bussacos, Ana C. M. et al. Redundancy of proteins in the salivary glands of Panstrongylus megistus secures prolonged procurement for blood meals. Journal of Proteomics, Amsterdam, v. 74, p. 1-8, 2011.