Lack of association of estrogen receptor alpha gene polymorphisms with cardiorespiratory and metabolic variables in young women
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Data
2012
Autores
Rebelo, Ana Cristina Silva
Verlengia, Rozangela
Kunz, Vandeni Clarice
Tamburús, Nayara Yamada
Maureira, Alvaro Danilo Cerda
Hirata, Rosario Dominguez Crespo
Hirata, Mario Hiroyuki
Silva, Ester da
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Resumo
This study examined the association of estrogen receptor alpha gene (ESR1)
polymorphisms with cardiorespiratory and metabolic parameters in young women. In total,
354 healthy women were selected for cardiopulmonary exercise testing and short-term
heart rate (HR) variability (HRV) evaluation. The HRV analysis was determined by the
temporal indices rMSSD (square root of the mean squared differences of successive R–R
intervals (RRi) divided by the number of RRi minus one), SDNN (root mean square of
differences from mean RRi, divided by the number of RRi) and power spectrum
components by low frequency (LF), high frequency (HF) and LF/HF ratio. Blood samples
were obtained for serum lipids, estradiol and DNA extraction. ESR1 rs2234693 and
rs9340799 polymorphisms were analyzed by PCR and fragment restriction analysis. HR and oxygen uptake (VO 2 ) values did not differ between the ESR1 polymorphisms with
respect to autonomic modulation. We not find a relationship between ESR1 T–A, T–G,
C–A and C–G haplotypes and cardiorespiratory and metabolic variables. Multiple linear
regression analysis demonstrated that VO 2 , total cholesterol and triglycerides influence HRV
(p < 0.05). The results suggest that ESR1 variants have no effect on cardiorespiratory
and metabolic variables, while HRV indices are influenced by aerobic capacity and lipids in
healthy women.
Descrição
Palavras-chave
Estrogen aerobic capacity, Heart rate variability, Lipids receptor-α gene polymorphisms
Citação
REBELO, Ana Cristina et al. Lack of association of estrogen receptor alpha gene polymorphisms with cardiorespiratory and metabolic variables in young women. International Journal of Molecular Sciences, Basel, v. 13, n. 10, p. 13691-13703, 2012.